Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GYS1 | P13807 | 7/20 | 0.36 |
| ▸ | HTR1D | P28221 | 1/20 | 0.32 |
| ▸ | JAK1 | P23458 | 2/20 | 0.32 |
| ▸ | PDK4 | Q16654 | 1/20 | 0.32 |
| ▸ | CCNT1 | O60563 | 3/20 | 0.31 |
| ▸ | CDK9 | P50750 | 3/20 | 0.31 |
| ▸ | EED | O75530 | 1/20 | 0.31 |
| ▸ | RBBP4 | Q09028 | 1/20 | 0.31 |
| ▸ | SUZ12 | Q15022 | 1/20 | 0.31 |
| ▸ | EZH2 | Q15910 | 1/20 | 0.31 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.31 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.31 |
| ▸ | WDR5 | P61964 | 1/20 | 0.31 |
| ▸ | GRM5 | P41594 | 1/20 | 0.31 |
| ▸ | GRM1 | Q13255 | 1/20 | 0.31 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6332995 | 0.90 | JAK1 (0.32) | HTR1DJAK1PDK4CCNT1CDK9 | |
| SCHEMBL6339270 | 0.82 | GYS1 (0.37) | GYS1HTR1DJAK1PDK4CCNT1 | |
| SCHEMBL6333427 | 0.82 | HTR2C (0.39) | PDK4WDR5 | |
| SCHEMBL6334303 | 0.82 | TSHR (0.32) | JAK1PDK4EEDRBBP4SUZ12 | |
| SCHEMBL1770789 | 0.74 | LMNA (0.34) | NR1H2NR1H3WDR5GRM5GRM1 | |
| SCHEMBL6492320 | 0.74 | HTR1D (0.37) | HTR1DJAK1PDK4CCNT1CDK9 | |
| SCHEMBL6334689 | 0.74 | NR1H2 (0.34) | GYS1HTR1DJAK1PDK4CCNT1 | |
| SCHEMBL6340611 | 0.73 | LMNA (0.33) | HTR1DJAK1PDK4CCNT1CDK9 | |
| SCHEMBL6492149 | 0.71 | TDO2 (0.46) | HTR1D | |
| SCHEMBL6504144 | 0.71 | HTR2A (0.36) | HTR1DJAK1PDK4NR1H2NR1H3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6881733-B1 | Serotonergic benzofurans | ELI LILLY AND COMPANY (US) | 2005-04-19 | — | — | US | disclosed |
| EP-1204659-B1 | SEROTONERGIC BENZOFURANS | LILLY CO ELI (US) | 2003-11-26 | — | — | EP | disclosed |
| EP-1204659-A2 | SEROTONERGIC BENZOFURANS | ELI LILLY AND COMPANY (US) | 2002-05-15 | — | — | EP | disclosed |
| WO-2001009122-A2 | SEROTONERGIC BENZOFURANS | ELI LILLY AND COMPANY (US) | 2001-02-08 | — | — | WO | disclosed |