Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Acrylamide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.41 |
| ▸ | TSHR | P16473 | 3/20 | 0.41 |
| ▸ | FGFR4 | P22455 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Acrylamide SCHEMBL11529251 | 0.88 | LMNA (0.47) | LMNAALDH1A1TSHRFGFR4MAPK1 | |
| Acrylamide SCHEMBL30226641 | 0.88 | — | — | |
| Acrylamide SCHEMBL647330 | 0.88 | — | — | |
| Acrylamide SCHEMBL7993747 | 0.88 | LMNA (0.47) | LMNAALDH1A1TSHRFGFR4MAPK1 | |
| Acrylamide SCHEMBL2689852 | 0.88 | — | — | |
| Acrylic Acid SCHEMBL29418960 | 0.77 | LMNA (0.44) | LMNAALDH1A1TSHRFGFR4MAPK1 | |
| Acrylic Acid SCHEMBL10363189 | 0.77 | LMNA (0.44) | LMNAALDH1A1TSHRFGFR4MAPK1 | |
| Acrylic Acid SCHEMBL6913278 | 0.72 | — | — | |
| Acrylic Acid SCHEMBL416966 | 0.72 | LMNA (0.47) | LMNAALDH1A1TSHRFGFR4MAPK1 | |
| Fumaric Acid SCHEMBL8986948 | 0.72 | LMNA (0.33) | LMNAALDH1A1TSHRFGFR4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050247639-A1 | Reduction in biological oxygen demand levels in waste water effluents | PURDUE RESESARCH FOUNDATION | 2005-11-10 | — | — | US | disclosed |
| EP-1503634-A1 | REDUCTION IN BIOLOGICAL OXYGEN DEMAND LEVELS IN WASTE WATER EFFLUENTS | PURDUE RESEARCH FOUNDATION (US) | 2005-02-09 | — | — | EP | disclosed |
| WO-2003090561-A1 | REDUCTION IN BIOLOGICAL OXYGEN DEMAND LEVELS IN WASTE WATER EFFLUENTS | PURDUE RESEARCH FOUNDATION (US) | 2003-11-06 | — | — | WO | disclosed |