Known targets — ChEMBL curated mechanism
ACEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ATP4AATP4BAXLBTKCACNA1CCACNA1DCACNA1FCACNA1SCCR5CHRM2CHRM3CPT1BCPT2DPP4DRD1DRD2EGFRERBB2ERBB4FLT3HRH1HRH3HTR1AHTR2AHTR2BHTR2CHTR4JAK1JAK2JAK3KCNH2KMT2AMAP2K1MAP2K2MEN1MLNRMPLMTORPPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PLK4PPARGRENS1PR1SLC6A2SLC6A3SLC6A4SMOTYK2atpAatpBatpCatpDatpEatpFatpFHatpGpol
The experimentally established mechanism targets of Fumaric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | CA1 | P00915 | 1/20 | 0.32 |
| ▸ | CA9 | Q16790 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | FGFR4 | P22455 | 1/20 | 0.32 |
| ▸ | BBOX1 | O75936 | 1/20 | 0.31 |
| ▸ | CA4 | P22748 | 1/20 | 0.30 |
| ▸ | FAHD1 | Q6P587 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Fumaric Acid SCHEMBL2389920 | 0.91 | LMNA (0.39) | LMNACA1CA9ALDH1A1TSHR | |
| Acrylic Acid SCHEMBL6913278 | 0.82 | — | — | |
| Acrylic Acid SCHEMBL1082680 | 0.82 | LMNA (0.47) | LMNACA1ALDH1A1TSHRFGFR4 | |
| Acrylic Acid SCHEMBL16257 | 0.82 | — | — | |
| Acrylamide SCHEMBL2689852 | 0.82 | — | — | |
| Acrylic Acid SCHEMBL819698 | 0.82 | LMNA (0.47) | LMNACA1CA9ALDH1A1TSHR | |
| Fumaric Acid SCHEMBL23629433 | 0.80 | LMNA (0.59) | LMNACA1CA9ALDH1A1TSHR | |
| SCHEMBL31556667 | 0.79 | CA1 (0.36) | CA1CA9TSHRBBOX1CA4 | |
| Acrylic Acid SCHEMBL9418472 | 0.78 | — | — | |
| Acrylic Acid SCHEMBL21246905 | 0.78 | LMNA (0.44) | LMNACA1ALDH1A1TSHRFGFR4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5520820-A | ACRYLAMIDE-ACRYLIC ACID-MALEIC ACID TERPOLYMER FLOCCULANT | ALLIED COLLOIDS LIMITED (GB) | 1996-05-28 | — | — | US | disclosed |