Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 1/20 | 1.00 |
| ▸ | PDE4B | Q07343 | 1/20 | 1.00 |
| ▸ | PDE4C | Q08493 | 1/20 | 1.00 |
| ▸ | PDE4D | Q08499 | 1/20 | 1.00 |
| ▸ | ABCG2 | Q9UNQ0 | 10/20 | 0.86 |
| ▸ | FLT3 | P36888 | 1/20 | 0.78 |
| ▸ | TNFRSF1A | P19438 | 3/20 | 0.72 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.69 |
| ▸ | ABCC1 | P33527 | 1/20 | 0.69 |
| ▸ | MEN1 | O00255 | 3/20 | 0.67 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.67 |
| ▸ | MAPT | P10636 | 2/20 | 0.66 |
| ▸ | ACHE | P22303 | 1/20 | 0.65 |
| ▸ | MAOB | P27338 | 1/20 | 0.65 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.64 |
| ▸ | POLB | P06746 | 1/20 | 0.64 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.64 |
| ▸ | TP53 | P04637 | 1/20 | 0.64 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.64 |
| ▸ | HPGD | P15428 | 1/20 | 0.64 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL633909 | 1.00 | PDE4A (1.00) | PDE4APDE4BPDE4CPDE4DABCG2 | |
| SCHEMBL633046 | 0.91 | ABCG2 (0.97) | PDE4APDE4BPDE4CPDE4DABCG2 | |
| SCHEMBL633045 | 0.91 | ABCG2 (0.97) | PDE4APDE4BPDE4CPDE4DABCG2 | |
| SCHEMBL634099 | 0.91 | PDE4A (0.82) | PDE4APDE4BPDE4CPDE4DABCG2 | |
| SCHEMBL634098 | 0.91 | PDE4A (0.82) | PDE4APDE4BPDE4CPDE4DABCG2 | |
| SCHEMBL21527669 | 0.90 | ABCG2 (1.00) | PDE4APDE4BPDE4CPDE4DABCG2 | |
| SCHEMBL21527670 | 0.90 | ABCG2 (1.00) | PDE4APDE4BPDE4CPDE4DABCG2 | |
| SCHEMBL25199780 | 0.88 | ABCG2 (1.00) | PDE4APDE4BPDE4CPDE4DABCG2 | |
| SCHEMBL8769002 | 0.88 | ABCG2 (0.80) | PDE4APDE4BPDE4CPDE4DABCG2 | |
| SCHEMBL5082183 | 0.88 | ABCG2 (1.00) | PDE4APDE4BPDE4CPDE4DABCG2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017132135-A1 | ESTROGEN RECEPTOR ALPHA COLIGANDS, AND METHODS OF USE THEREOF | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2017-08-03 | — | — | WO | disclosed |
| EP-1888174-B1 | USE OF CHALCONES FOR THE TREATMENT OF VIRAL DISORDERS | JOHNSON & JOHNSON CONSUMER (US) | 2012-02-22 | — | — | EP | disclosed |
| US-20060270614-A1 | Use of chalcones for the treatment of viral disorders | JOHNSON & JOHNSON CONSUMER COMPANIES, INC. | 2006-11-30 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060270614-A1 | Use of chalcones for the treatment of viral disorders | HAVCR2, HMGB3, EIF2AK2 | PDE4A 3695/4885PDE4B 3845/4885PDE4C 3869/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.