Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IDO1 | P14902 | 1/20 | 0.64 |
| ▸ | TDO2 | P48775 | 1/20 | 0.64 |
| ▸ | SIGMAR1 | Q99720 | 12/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.51 |
| ▸ | TP53 | P04637 | 1/20 | 0.51 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.51 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.51 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.51 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.51 |
| ▸ | TSHR | P16473 | 1/20 | 0.51 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.51 |
| ▸ | RBP4 | P02753 | 1/20 | 0.50 |
| ▸ | OPRL1 | P41146 | 3/20 | 0.49 |
| ▸ | SLC18A3 | Q16572 | 2/20 | 0.48 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.47 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.46 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.46 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13664908 | 0.85 | SIGMAR1 (0.56) | IDO1TDO2SIGMAR1ALDH1A1TP53 | |
| SCHEMBL4061440 | 0.83 | IDO1 (0.58) | IDO1TDO2SIGMAR1ALDH1A1TP53 | |
| SCHEMBL9479601 | 0.80 | CYP2D6 (0.54) | IDO1TDO2SIGMAR1ALDH1A1TP53 | |
| SCHEMBL14112074 | 0.80 | SIGMAR1 (0.50) | IDO1TDO2SIGMAR1ALDH1A1TP53 | |
| SCHEMBL1223501 | 0.78 | RBP4 (0.62) | IDO1TDO2SIGMAR1ALDH1A1TP53 | |
| SCHEMBL3719812 | 0.77 | KDM4E (0.54) | ALDH1A1TSHRKCNH2 | |
| SCHEMBL6169664 | 0.77 | SIGMAR1 (0.56) | SIGMAR1ALDH1A1TP53CYP1A2CYP3A4 | |
| SCHEMBL14986259 | 0.77 | SIGMAR1 (0.58) | IDO1TDO2SIGMAR1ALDH1A1TP53 | |
| SCHEMBL14379213 | 0.76 | SIGMAR1 (0.45) | IDO1TDO2SIGMAR1ALDH1A1TP53 | |
| SCHEMBL14379218 | 0.76 | SIGMAR1 (0.45) | IDO1TDO2SIGMAR1ALDH1A1TP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6869960-B2 | N-substituted spiropiperidine compounds as ligands for ORL-1 receptor | PFIZER INC. (US) | 2005-03-22 | — | — | US | disclosed |
| EP-1470126-A1 | N-SUBSTITUTED SPIROPIPERIDINE COMPOUNDS AS LIGANDS FOR ORL-1 RECEPTOR | PFIZER INC. (US) | 2004-10-27 | — | — | EP | disclosed |
| US-20030158219-A1 | N-substituted spiropiperidine compounds as ligands for ORL-1 receptor | ITO FUMITAKA (JP) | 2003-08-21 | — | — | US | disclosed |
| WO-2003064425-A1 | N-SUBSTITUTED SPIROPIPERIDINE COMPOUNDS AS LIGANDS FOR ORL-1 RECEPTOR | PFIZER JAPAN INC. (JP) | 2003-08-07 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030158219-A1 | N-substituted spiropiperidine compounds as ligands for ORL-1 receptor | OGFRL1, OXER1, ORMDL3 | IDO1 3672/4885TDO2 4180/4885SIGMAR1 13/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.