Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.55 |
| ▸ | TSHR | P16473 | 1/20 | 0.55 |
| ▸ | HPGD | P15428 | 1/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.49 |
| ▸ | RAB9A | P51151 | 4/20 | 0.47 |
| ▸ | MEN1 | O00255 | 3/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.47 |
| ▸ | NPC1 | O15118 | 3/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.47 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.47 |
| ▸ | MAOB | P27338 | 1/20 | 0.46 |
| ▸ | CTSD | P07339 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27992608 | 0.85 | ALDH1A1 (0.58) | ALDH1A1TSHRHPGDL3MBTL1RAB9A | |
| SCHEMBL8872041 | 0.84 | ALDH1A1 (0.58) | ALDH1A1TSHRHPGDL3MBTL1RAB9A | |
| SCHEMBL1573514 | 0.84 | ALDH1A1 (0.56) | ALDH1A1TSHRHPGDL3MBTL1RAB9A | |
| SCHEMBL6002942 | 0.84 | ALDH1A1 (0.56) | ALDH1A1TSHRHPGDL3MBTL1RAB9A | |
| SCHEMBL10752489 | 0.82 | ALDH1A1 (0.55) | ALDH1A1TSHRHPGDL3MBTL1RAB9A | |
| SCHEMBL29383344 | 0.82 | ALDH1A1 (0.55) | ALDH1A1TSHRHPGDL3MBTL1RAB9A | |
| SCHEMBL1573285 | 0.82 | ALDH1A1 (0.59) | ALDH1A1TSHRHPGDL3MBTL1RAB9A | |
| SCHEMBL7733004 | 0.82 | ALDH1A1 (0.55) | ALDH1A1TSHRHPGDL3MBTL1RAB9A | |
| SCHEMBL151684 | 0.82 | ALDH1A1 (0.55) | ALDH1A1TSHRHPGDL3MBTL1RAB9A | |
| SCHEMBL3290647 | 0.81 | ALDH1A1 (0.53) | ALDH1A1TSHRHPGDL3MBTL1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050026908-A1 | Carboxylic acid derivatives, processes for the preparation thereof and pharmaceutical aggents comprising the same as active ingredient | ONO PHARMACEUTICAL CO., LTD. | 2005-02-03 | — | — | US | disclosed |
| US-6835752-B2 | Can bind to Prostaglandin E2 receptors, especially, EP3 receptor and/or EP4 receptor and show antagonizing activity, and may be useful for prevention and/or treatment of disease, for example, pain, allergy, Alzheimer's disease, cancer | ONO PHARMACEUTICAL CO., LTD. (JP) | 2004-12-28 | — | — | US | disclosed |
| US-20040235825-A1 | Carboxylic acid derivatives, processes for the preparation thereof and pharmaceutical agents comprising the same as active ingredient | ONO PHARMACEUTICAL CO., LTD. | 2004-11-25 | — | — | US | disclosed |
| US-20030216381-A1 | Carboxylic acid derivatives, process for producing the same and drugs containing the same as the active ingredient | ONO PHARMACEUTICAL CO., LTD. (JP) | 2003-11-20 | — | — | US | disclosed |
| EP-1312601-A1 | CARBOXYLIC ACID DERIVATIVES, PROCESS FOR PRODUCING THE SAME AND DRUGS CONTAINING THE SAME AS THE ACTIVE INGREDIENT | ONO PHARMACEUTICAL CO., LTD. (JP) | 2003-05-21 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050026908-A1 | Carboxylic acid derivatives, processes for the preparation thereof and pharmaceutical aggents comprising the same as active ingredient | PTGER4, PTGER3, LTB4R | ALDH1A1 399/4885TSHR 2539/4885HPGD 195/4885 |
| US-20040235825-A1 | Carboxylic acid derivatives, processes for the preparation thereof and pharmaceutical agents comprising the same as active ingredient | PTGER4, PTGER1, LTB4R | ALDH1A1 224/4885TSHR 2511/4885HPGD 128/4885 |
| US-20030216381-A1 | Carboxylic acid derivatives, process for producing the same and drugs containing the same as the active ingredient | PTGER4, PTGER1, PTGER2 | ALDH1A1 212/4885TSHR 2553/4885HPGD 162/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.