Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAD52 | P43351 | 6/20 | 0.49 |
| ▸ | POLR1A | O95602 | 5/20 | 0.48 |
| ▸ | ECE1 | P42892 | 1/20 | 0.48 |
| ▸ | MUS81 | Q96NY9 | 1/20 | 0.48 |
| ▸ | AOX1 | Q06278 | 1/20 | 0.48 |
| ▸ | UHRF1 | Q96T88 | 1/20 | 0.48 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.46 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.44 |
| ▸ | SMARCA2 | P51531 | 1/20 | 0.43 |
| ▸ | PARP1 | P09874 | 1/20 | 0.42 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.42 |
| ▸ | BRD4 | O60885 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30122363 | 1.00 | RAD52 (0.49) | RAD52POLR1AECE1MUS81AOX1 | |
| SCHEMBL30122373 | 1.00 | RAD52 (0.49) | RAD52POLR1AECE1MUS81AOX1 | |
| SCHEMBL29058295 | 0.94 | POLR1A (0.50) | RAD52POLR1AECE1MUS81AOX1 | |
| SCHEMBL30122275 | 0.94 | POLR1A (0.50) | RAD52POLR1AECE1MUS81AOX1 | |
| SCHEMBL634104 | 0.91 | POLR1A (0.50) | RAD52POLR1AECE1MUS81AOX1 | |
| SCHEMBL21798703 | 0.90 | POLR1A (0.42) | RAD52POLR1AECE1MUS81AOX1 | |
| SCHEMBL21798677 | 0.89 | LMNA (0.48) | POLR1AHTTCYP1A2KDM4EALDH1A1 | |
| SCHEMBL634412 | 0.88 | POLR1A (0.48) | RAD52POLR1AECE1MUS81AOX1 | |
| SCHEMBL31125271 | 0.88 | RAD52 (0.48) | RAD52POLR1AECE1MUS81AOX1 | |
| SCHEMBL635572 | 0.88 | RAD52 (0.48) | RAD52POLR1AECE1MUS81AOX1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1507778-B1 | ANTI-TUMOUR POLYCYCLIC CARBOXAMIDES | UNIV TROBE (AU) | 2012-02-22 | — | — | EP | claimed |
| US-7504507-B2 | Anti-tumour polycyclic carboxamides | AUCKLAND UNISERVICES LIMITED (NZ) | 2009-03-17 | — | — | US | claimed |
| US-20050245561-A1 | Anti-tumour polycyclic carboxamides | AUCKLAND UNISERVICES LIMITED (NZ) | 2005-11-03 | — | — | US | claimed |
| CN-115677691-B | Preparation method of benzonaphthyridine amide anticancer drug SN28049 and analogues thereof | 潍坊富邦药业有限公司 | 2023-08-29 | — | — | CN | disclosed |
| CN-115677691-A | Preparation method of benzonaphthyridine amide anticancer drug SN28049 and analogues thereof | 潍坊富邦药业有限公司 | 2023-02-03 | — | — | CN | disclosed |
| US-11046687-B2 | Polycyclic amide compound, preparation process and use thereof | HEBEI GRANDIOS PHARMA CO., LTD. | 2021-06-29 | — | — | US | disclosed |
| EP-1507778-B1 | ANTI-TUMOUR POLYCYCLIC CARBOXAMIDES | UNIV TROBE (AU) | 2012-02-22 | — | — | EP | disclosed |
| US-20090156630-A1 | ANTI-TUMOUR POLYCYCLIC CARBOXAMIDES | BAGULEY BRUCE CHARLES | 2009-06-18 | — | — | US | disclosed |
| US-7504507-B2 | Anti-tumour polycyclic carboxamides | AUCKLAND UNISERVICES LIMITED (NZ) | 2009-03-17 | — | — | US | disclosed |
| US-20080248134-A1 | Oral compositions, use and combinations of N-[2-(dimethylamino)ethyl]-2,6 dimethyl-1-oxo-1,2-dihydrobenzo[b]-1,6-naphthyridine-4-carboxamide and closely related analogues thereof | AUCKLAND UNISERVICES LIMITED (NZ) | 2008-10-09 | — | — | US | disclosed |
| US-20080248134-A1 | Oral compositions, use and combinations of N-[2-(dimethylamino)ethyl]-2,6 dimethyl-1-oxo-1,2-dihydrobenzo[b]-1,6-naphthyridine-4-carboxamide and closely related analogues thereof | AUCKLAND UNISERVICES LIMITED (NZ) | 2008-10-09 | — | — | US | disclosed |
| US-20050245561-A1 | Anti-tumour polycyclic carboxamides | AUCKLAND UNISERVICES LIMITED (NZ) | 2005-11-03 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090156630-A1 | ANTI-TUMOUR POLYCYCLIC CARBOXAMIDES | MKI67, MCL1, CCNI | RAD52 2694/4885POLR1A 833/4885ECE1 956/4885 |
| US-20080248134-A1 | Oral compositions, use and combinations of N-[2-(dimethylamino)ethyl]-2,6 dimethyl-1-oxo-1,2-dihydrobenzo[b]-1,6-naphthyridine-4-carboxamide and closely related analogues thereof | MCL1, ACIN1, CCNA1 | RAD52 2055/4885POLR1A 216/4885ECE1 1867/4885 |
| US-20050245561-A1 | Anti-tumour polycyclic carboxamides | MKI67, MCL1, CCNI | RAD52 2746/4885POLR1A 791/4885ECE1 1068/4885 |
| US-11046687-B2 | Polycyclic amide compound, preparation process and use thereof | H4C1; H4C2; H4C3; H4C4; H4C5; H4C6; H4C8; H4C9; H4C11; H4C12; H4C13; H4C14; H4C15; H4C16, UACA, H1-0 | RAD52 2751/4885POLR1A 500/4885ECE1 2712/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.