Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 1/20 | 0.38 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 2/20 | 0.37 |
| ▸ | LMNA | P02545 | 2/20 | 0.35 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.35 |
| ▸ | DRD2 | P14416 | 1/20 | 0.35 |
| ▸ | HTR7 | P34969 | 1/20 | 0.35 |
| ▸ | S1PR1 | P21453 | 4/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.34 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 3/20 | 0.33 |
| ▸ | MEN1 | O00255 | 2/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | USP2 | O75604 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | RECQL | P46063 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | S1PR3 | Q99500 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6344215 | 0.92 | HDAC1 (0.36) | HDAC1HDAC6TP53LMNACHRM4 | |
| SCHEMBL6343620 | 0.90 | GPR119 (0.42) | HDAC1HDAC6LMNANPSR1GPR119 | |
| SCHEMBL6342867 | 0.84 | NR1H2 (0.38) | HDAC1HDAC6LMNANPSR1GPR119 | |
| SCHEMBL6340943 | 0.84 | CCR5 (0.37) | HDAC1HDAC6GPR119MAPTALDH1A1 | |
| SCHEMBL6351963 | 0.83 | GPR119 (0.37) | HDAC1HDAC6GPR119MAPTALDH1A1 | |
| SCHEMBL6343395 | 0.81 | KDM4E (0.39) | TP53LMNAS1PR1NPSR1MAPT | |
| SCHEMBL6338733 | 0.80 | NR1H2 (0.36) | HDAC1HDAC6CHRM4DRD2HTR7 | |
| SCHEMBL6351797 | 0.80 | RET (0.37) | HDAC1HDAC6GPR119 | |
| SCHEMBL6340987 | 0.80 | GPR119 (0.44) | HDAC1HDAC6GPR119MAPTMEN1 | |
| SCHEMBL6341447 | 0.79 | USP30 (0.41) | HDAC1HDAC6CHRM4DRD2HTR7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6936602-B1 | Benzazepine derivatives, process for the preparation of the same and uses thereof | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 2005-08-30 | — | — | US | disclosed |
| EP-1186604-A1 | BENZAZEPINE DERIVATIVES, PROCESS FOR THE PREPARATION OF THE SAME AND USES THEREOF | Takeda Chemical Industries, Ltd. (JP) | 2002-03-13 | — | — | EP | disclosed |