Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.44 |
| ▸ | PIK3CA | P42336 | 6/20 | 0.39 |
| ▸ | MTOR | P42345 | 3/20 | 0.39 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.38 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | PRKDC | P78527 | 1/20 | 0.36 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.36 |
| ▸ | AOC3 | Q16853 | 1/20 | 0.36 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.36 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.36 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6338749 | 0.91 | MRGPRX4 (0.39) | PIK3CAMTORMRGPRX4KMT2AMEN1 | |
| SCHEMBL6339471 | 0.88 | SMN1; SMN2 (0.42) | PIK3CAMTORMRGPRX4KMT2AMEN1 | |
| SCHEMBL6341522 | 0.84 | MAPT (0.38) | KMT2AMEN1AOC3NPC1MAPT | |
| SCHEMBL6343620 | 0.82 | GPR119 (0.42) | GPR119KMT2AMEN1HDAC1HDAC6 | |
| SCHEMBL6340485 | 0.81 | MRGPRX4 (0.38) | PIK3CAMTORMRGPRX4KMT2AMEN1 | |
| SCHEMBL6342867 | 0.81 | NR1H2 (0.38) | GPR119HDAC1HDAC6MAPTSMN1; SMN2 | |
| SCHEMBL6339599 | 0.80 | TP53 (0.41) | PIK3CAMTORMRGPRX4KMT2AMEN1 | |
| SCHEMBL6340953 | 0.80 | HDAC1 (0.38) | GPR119KMT2AMEN1HDAC1HDAC6 | |
| SCHEMBL6341447 | 0.79 | USP30 (0.41) | KMT2AMEN1HDAC1HDAC6SMN1; SMN2 | |
| SCHEMBL6338733 | 0.79 | NR1H2 (0.36) | GPR119HDAC1HDAC6MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6936602-B1 | Benzazepine derivatives, process for the preparation of the same and uses thereof | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 2005-08-30 | — | — | US | disclosed |
| EP-1186604-A1 | BENZAZEPINE DERIVATIVES, PROCESS FOR THE PREPARATION OF THE SAME AND USES THEREOF | Takeda Chemical Industries, Ltd. (JP) | 2002-03-13 | — | — | EP | disclosed |