Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.38 |
| ▸ | AOC3 | Q16853 | 3/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.38 |
| ▸ | MEN1 | O00255 | 4/20 | 0.38 |
| ▸ | MAPT | P10636 | 3/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | PIK3CA | P42336 | 3/20 | 0.36 |
| ▸ | PIK3CG | P48736 | 3/20 | 0.36 |
| ▸ | MTOR | P42345 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | PKM | P14618 | 1/20 | 0.36 |
| ▸ | CCR5 | P51681 | 3/20 | 0.36 |
| ▸ | PIK3CD | O00329 | 2/20 | 0.35 |
| ▸ | PIK3CB | P42338 | 2/20 | 0.35 |
| ▸ | PIK3R2 | O00459 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6343442 | 0.88 | AOC3 (0.40) | AOC3KMT2AMEN1MAPTSMN1; SMN2 | |
| SCHEMBL6338749 | 0.85 | MRGPRX4 (0.39) | MRGPRX4AOC3KMT2AMEN1MAPT | |
| SCHEMBL6339471 | 0.85 | SMN1; SMN2 (0.42) | MRGPRX4AOC3KMT2AMEN1MAPT | |
| SCHEMBL6339599 | 0.83 | TP53 (0.41) | MRGPRX4KMT2AMEN1MAPTSMN1; SMN2 | |
| SCHEMBL6340987 | 0.81 | GPR119 (0.44) | MRGPRX4AOC3KMT2AMEN1MAPT | |
| SCHEMBL6351503 | 0.81 | ALDH1A1 (0.43) | KMT2AMEN1MAPTNPC1RAB9A | |
| SCHEMBL6349873 | 0.79 | ERN1 (0.39) | MAPTSMN1; SMN2KDM4EALDH1A1CCR5 | |
| SCHEMBL6343395 | 0.78 | KDM4E (0.39) | KMT2AMEN1MAPTKDM4ELMNA | |
| SCHEMBL6339467 | 0.78 | MRGPRX4 (0.41) | MRGPRX4AOC3KMT2AMEN1MAPT | |
| SCHEMBL7685365 | 0.78 | MRGPRX4 (0.41) | MRGPRX4AOC3KMT2AMEN1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6936602-B1 | Benzazepine derivatives, process for the preparation of the same and uses thereof | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 2005-08-30 | — | — | US | disclosed |
| EP-1186604-A1 | BENZAZEPINE DERIVATIVES, PROCESS FOR THE PREPARATION OF THE SAME AND USES THEREOF | Takeda Chemical Industries, Ltd. (JP) | 2002-03-13 | — | — | EP | disclosed |