Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCNE1 | P24864 | 2/20 | 0.37 |
| ▸ | CDK2 | P24941 | 2/20 | 0.37 |
| ▸ | LMNA | P02545 | 4/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | EGFR | P00533 | 3/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.34 |
| ▸ | HPGD | P15428 | 2/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.33 |
| ▸ | GFER | P55789 | 2/20 | 0.33 |
| ▸ | MEN1 | O00255 | 2/20 | 0.33 |
| ▸ | AGER | Q15109 | 1/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL631725 | 0.86 | AGER (0.42) | CCNE1CDK2LMNASMN1; SMN2MAPT | |
| SCHEMBL632224 | 0.86 | ALDH1A1 (0.39) | MAPTALDH1A1CYP1A2CYP2C9HPGD | |
| SCHEMBL632032 | 0.86 | MAPT (0.44) | LMNASMN1; SMN2POLBMAPTALDH1A1 | |
| SCHEMBL632231 | 0.77 | ALDH1A1 (0.38) | SMN1; SMN2ALDH1A1CYP1A2CYP2C9HPGD | |
| SCHEMBL632743 | 0.76 | MAPT (0.41) | LMNASMN1; SMN2MAPTALDH1A1CYP1A2 | |
| SCHEMBL631864 | 0.75 | KDM4E (0.47) | SMN1; SMN2EGFRALDH1A1CYP1A2CYP2C19 | |
| SCHEMBL631355 | 0.74 | MAPT (0.44) | SMN1; SMN2MAPTALDH1A1HPGDL3MBTL1 | |
| SCHEMBL632321 | 0.74 | NPC1 (0.43) | POLBMAPTALDH1A1CYP1A2CYP2C9 | |
| SCHEMBL632276 | 0.73 | SMN1; SMN2 (0.52) | LMNASMN1; SMN2MAPTEGFRALDH1A1 | |
| SCHEMBL632601 | 0.71 | LMNA (0.44) | LMNASMN1; SMN2MAPTALDH1A1L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2076497-B1 | AMINOMETHYL-4-IMIDAZOLES | HOFFMANN LA ROCHE (CH) | 2012-02-22 | — | — | EP | claimed |