Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP19A1 | P11511 | 2/20 | 0.50 |
| ▸ | CFTR | P13569 | 1/20 | 0.47 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.47 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.47 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.47 |
| ▸ | GOPC | Q9HD26 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | KCNA5 | P22460 | 7/20 | 0.42 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | KCNN4 | O15554 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4452260 | 0.81 | SMN1; SMN2 (0.50) | CYP19A1CFTRSLC6A2SLC6A4SLC6A3 | |
| SCHEMBL12303932 | 0.81 | CYP19A1 (0.47) | CYP19A1CFTRSLC6A2SLC6A4SLC6A3 | |
| SCHEMBL4452256 | 0.81 | SMN1; SMN2 (0.50) | CYP19A1CFTRSLC6A2SLC6A4SLC6A3 | |
| SCHEMBL128718 | 0.81 | CFTR (0.53) | CYP19A1CFTRSLC6A2SLC6A4SLC6A3 | |
| SCHEMBL9175652 | 0.81 | FDPS (0.48) | CYP19A1CFTRSLC6A2SLC6A4SLC6A3 | |
| SCHEMBL12251226 | 0.79 | CYP19A1 (0.45) | CYP19A1CFTRSLC6A2SLC6A4SLC6A3 | |
| SCHEMBL19592373 | 0.78 | CYP19A1 (0.44) | CYP19A1CFTRSLC6A2SLC6A4SLC6A3 | |
| SCHEMBL18896339 | 0.75 | CYP19A1 (0.42) | CYP19A1CFTRSLC6A2SLC6A4SLC6A3 | |
| SCHEMBL7007862 | 0.74 | ESR1 (0.47) | SMN1; SMN2 | |
| SCHEMBL19592285 | 0.74 | CTSL (0.43) | CYP19A1SMN1; SMN2KCNA5KCNH2LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6946554-B2 | Process for the preparation of 9-deazaguanine derivatives | BIOCRYST PHARMACEUTICALS, INC. (US) | 2005-09-20 | — | — | US | disclosed |
| EP-0970029-A1 | PROCESS FOR THE PREPARATION OF 9-DEAZAGUANINE DERIVATIVES | BIOCRYST PHARMACEUTICALS INC. (US) | 2000-01-12 | — | — | EP | disclosed |
| US-5650511-A | MULTISTAGE REACTION OF ALDEHYDE OR KETONE WITH NITRILE GROUP TO FORM ENAMINE, REACTION OF ENAMINE WITH BASE TO FORM PYRROLE, THEN REACTION | BIOCRYST PHARMACEUTICALS, INC. (US) | 1997-07-22 | — | — | US | disclosed |
| WO-1997021653-A1 | PROCESS FOR THE PREPARATION OF 9-DEAZAGUANINE DERIVATIVES | BIOCRYST PHARMACEUTICALS, INC. (US) | 1997-06-19 | — | — | WO | disclosed |