Sugi Predict

Sugi Predict / Compounds / SCHEMBL6344255

SCHEMBL6344255

SCHEMBL6344255

c1ccc(Cc2cc3ccccc3s2)cc1

nearest known ligand 0.60

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
▸ CYP2A6 P11509 4/20 0.60
▸ ASIC3 Q9UHC3 1/20 0.60
▸ LOXL2 Q9Y4K0 1/20 0.60
▸ ADRB2 P07550 1/20 0.59
▸ AGXT P21549 1/20 0.55
▸ ADRA1D P25100 2/20 0.53
▸ SLC5A2 P31639 4/20 0.50
▸ IDH1 O75874 1/20 0.47
▸ BCL2L1 Q07817 1/20 0.44
▸ CALM1 P0DP23 1/20 0.42
▸ ADORA2A P29274 1/20 0.42
▸ ADORA1 P30542 1/20 0.42
▸ ALDH1A1 P00352 1/20 0.42
▸ HPGD P15428 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7338114 1.00 CYP2A6 (0.60) CYP2A6ASIC3LOXL2ADRB2AGXT
SCHEMBL30047288 0.89 CYP2A6 (0.53) CYP2A6ASIC3LOXL2ADRB2AGXT
SCHEMBL4961407 0.87 CYP2A6 (0.69) CYP2A6ASIC3LOXL2ADRB2AGXT
SCHEMBL6968526 0.85 NR1D1 (0.53) CYP2A6ASIC3LOXL2ADRB2AGXT
SCHEMBL6971248 0.85 CYP2A6 (0.57) CYP2A6ASIC3LOXL2ADRB2AGXT
SCHEMBL1539256 0.83 SLC5A2 (0.50) CYP2A6ASIC3LOXL2ADRB2AGXT
SCHEMBL6970206 0.81 CYP2A6 (0.53) CYP2A6ASIC3LOXL2ADRB2AGXT
SCHEMBL7086153 0.81 CYP2A6 (0.53) CYP2A6ASIC3LOXL2ADRB2AGXT
SCHEMBL25444211 0.81 ADORA2A (0.40) CYP2A6ASIC3LOXL2ADRB2AGXT
SCHEMBL12425730 0.80 CYP2A6 (0.51) CYP2A6ASIC3LOXL2ADRB2AGXT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 39 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-113185350-A Weeding type bio-organic fertilizer, preparation method and application 中科韶华(四川)牧业研究院有限公司 2021-07-30 — — CN claimed
CN-107629033-A A kind of synthetic method of [60] fullerene benzothiophene derivative that DDQ promotes 河南师范大学 2018-01-26 — — CN claimed
CN-113185350-A Weeding type bio-organic fertilizer, preparation method and application 中科韶华(四川)牧业研究院有限公司 2021-07-30 — — CN disclosed
CN-107629033-A A kind of synthetic method of [60] fullerene benzothiophene derivative that DDQ promotes 河南师范大学 2018-01-26 — — CN disclosed
CN-107629033-A A kind of synthetic method of [60] fullerene benzothiophene derivative that DDQ promotes 河南师范大学 2018-01-26 — — CN disclosed
US-6844358-B2 Phenyl oxo-acetic acids useful in the treatment of insulin resistance and hyperglycemia WYETH (US) 2005-01-18 — — US disclosed
US-20040102480-A1 Phenyl oxo-acetic acids useful in the treatment of insulin resistance and hyperglycemia WYETH (US) 2004-05-27 — — US disclosed
US-6683107-B2 THERAPY OF METABOLISM DISORDERS WYETH 2004-01-27 — — US disclosed
US-6613804-B2 Treatment of hypertension, cardiovascular disease, pulmonary hypertension, erythropoietin-mediated vasoconstriction, endotoxin shock, pulmonary hypertension, anaphylactic shock and hemorrhagic shock ENCYSIVE PHARMACEUTICALS, INC. 2003-09-02 — — US disclosed
EP-0819125-B1 THIENYL-, FURYL-, PYRROLYL- AND BIPHENYLSULFONAMIDES AND DERIVATIVES THEREOF THAT MODULATE THE ACTIVITY OF ENDOTHELIN TEXAS BIOTECHNOLOGY CORP (US) 2003-06-18 — — EP disclosed
US-20030073709-A1 Furans, benzofurans, and thiophenes useful in the treatment of insulin resistance and hyperglycemia WYETH 2003-04-17 — — US disclosed
WO-1996031492-A1 THIENYL-, FURYL-, PYRROLYL- AND BIPHENYLSULFONAMIDES AND DERIVATIVES THEREOF THAT MODULATE THE ACTIVITY OF ENDOTHELIN TEXAS BIOTECHNOLOGY CORPORATION (US) 1996-10-10 — — WO disclosed
EP-0207605-B1 HYPOGLYCEMIC THIAZOLIDINEDIONES PFIZER INC. (US) 1990-02-07 — — EP disclosed
US-4703052-A Hypoglycemic thiazolidinediones PFIZER INC. (US) 1987-10-27 — — US disclosed
EP-0207605-A1 Hypoglycemic thiazolidinediones PFIZER INC. (US) 1987-01-07 — — EP disclosed
WO-1986007056-A1 HYPOGLYCEMIC THIAZOLIDINEDIONES PFIZER INC. (US) 1986-12-04 — — WO disclosed
US-4117128-A SULFONYL BENZOFURANS AND BENZOTHIOPHENES HAVING CORONARY VASODILATOR ACTIVITY SMITHKLINE CORPORATION (US) 1978-09-26 — — US disclosed
US-4024273-A Coronary vasodilator and anti-anginal compositions comprising substituted benzofurans and benzothiophenes and methods of producing coronary vasodilation and anti-anginal activity SMITHKLINE CORPORATION (US) 1977-05-17 — — US disclosed
US-3983245-A CORONARY VASODILATORS SMITHKLINE CORPORATION (US) 1976-09-28 — — US disclosed
US-3947470-A CORONARY VASODILATORS, TREATMENT OF ANGINA PECTORIS SMITHKLINE CORPORATION (US) 1976-03-30 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20030073709-A1 Furans, benzofurans, and thiophenes useful in the treatment of insulin resistance and hyperglycemia GPR119, INSR, FFAR3 CYP2A6 213/4885ASIC3 1556/4885LOXL2 3857/4885
US-20040102480-A1 Phenyl oxo-acetic acids useful in the treatment of insulin resistance and hyperglycemia GPR119, INSR, GCKR CYP2A6 206/4885ASIC3 961/4885LOXL2 3593/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.