Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABCB1 | P08183 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 2/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
| ▸ | SRC | P12931 | 8/20 | 0.37 |
| ▸ | GPR119 | Q8TDV5 | 2/20 | 0.37 |
| ▸ | P2RX3 | P56373 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24739036 | 0.90 | ABCB1 (0.54) | ABCB1MEN1KMT2ASRC | |
| SCHEMBL24739417 | 0.90 | ABCB1 (0.54) | ABCB1MEN1KMT2ASRC | |
| SCHEMBL24739230 | 0.87 | P2RX3 (0.44) | MEN1KMT2AALDH1A1LMNAGAA | |
| SCHEMBL6338200 | 0.84 | ABCB1 (0.47) | ABCB1MEN1KMT2ACACNA1BGAA | |
| SCHEMBL24739114 | 0.80 | TP53 (0.38) | ABCB1ALDH1A1SRCP2RX3POLB | |
| SCHEMBL24739538 | 0.80 | TP53 (0.38) | ABCB1ALDH1A1SRCP2RX3POLB | |
| SCHEMBL24739168 | 0.79 | SRC (0.36) | ABCB1MEN1KMT2AALDH1A1SRC | |
| SCHEMBL24739530 | 0.79 | SRC (0.42) | ABCB1MEN1KMT2ASRC | |
| SCHEMBL24739129 | 0.79 | MCL1 (0.42) | SRCGPR119P2RX3CYP1A2CYP3A4 | |
| SCHEMBL3180068 | 0.78 | ABCB1 (0.44) | ABCB1ALDH1A1GPR119P2RX3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6878736-B1 | Histamine H3 receptor ligands | JAMES BLACK FOUNDATION LIMITED (GB) | 2005-04-12 | — | — | US | disclosed |