Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABCB1 | P08183 | 1/20 | 0.47 |
| ▸ | GPR119 | Q8TDV5 | 5/20 | 0.39 |
| ▸ | P2RX3 | P56373 | 1/20 | 0.37 |
| ▸ | MC4R | P32245 | 3/20 | 0.36 |
| ▸ | MC3R | P41968 | 3/20 | 0.36 |
| ▸ | MC1R | Q01726 | 3/20 | 0.36 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.36 |
| ▸ | BDKRB2 | P30411 | 2/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.35 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.35 |
| ▸ | CARM1 | Q86X55 | 1/20 | 0.34 |
| ▸ | PRMT6 | Q96LA8 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5996840 | 0.84 | MC4R (0.52) | ABCB1GPR119MC4RMC3RMC1R | |
| SCHEMBL6344298 | 0.84 | ABCB1 (0.45) | ABCB1GPR119P2RX3CACNA1BSMN1; SMN2 | |
| SCHEMBL2980458 | 0.81 | ABCB1 (0.57) | ABCB1MC4RMC3RMC1RBDKRB2 | |
| SCHEMBL8133927 | 0.81 | ABCB1 (0.44) | ABCB1GPR119P2RX3MCL1OPRK1 | |
| SCHEMBL3180068 | 0.81 | ABCB1 (0.44) | ABCB1GPR119P2RX3MCL1OPRK1 | |
| SCHEMBL6339615 | 0.80 | ABCB1 (0.41) | ABCB1GPR119P2RX3HTTSMN1; SMN2 | |
| SCHEMBL3190398 | 0.79 | P2RX3 (0.54) | ABCB1GPR119P2RX3CACNA1BMCL1 | |
| SCHEMBL8170628 | 0.79 | P2RX3 (0.54) | ABCB1GPR119P2RX3CACNA1BMCL1 | |
| SCHEMBL21996640 | 0.79 | ABCB1 (0.48) | ABCB1GPR119 | |
| SCHEMBL28995867 | 0.78 | ABCB1 (0.58) | ABCB1GPR119BDKRB2MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6878736-B1 | Histamine H3 receptor ligands | JAMES BLACK FOUNDATION LIMITED (GB) | 2005-04-12 | — | — | US | disclosed |