Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3B | P49841 | 9/20 | 0.41 |
| ▸ | PRKCB | P05771 | 6/20 | 0.41 |
| ▸ | PRKCA | P17252 | 6/20 | 0.41 |
| ▸ | PRKCG | P05129 | 5/20 | 0.38 |
| ▸ | KCNH2 | Q12809 | 4/20 | 0.38 |
| ▸ | PRKCZ | Q05513 | 3/20 | 0.38 |
| ▸ | PRKCD | Q05655 | 3/20 | 0.38 |
| ▸ | CDK2 | P24941 | 2/20 | 0.37 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.37 |
| ▸ | PIM1 | P11309 | 1/20 | 0.37 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.37 |
| ▸ | CDK9 | P50750 | 1/20 | 0.37 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.37 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.37 |
| ▸ | CCNE2 | O96020 | 1/20 | 0.35 |
| ▸ | CDK4 | P11802 | 1/20 | 0.35 |
| ▸ | CCND1 | P24385 | 1/20 | 0.35 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.35 |
| ▸ | ELANE | P08246 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1127976 | 0.85 | GSK3B (0.56) | GSK3BPRKCBPRKCAPRKCGKCNH2 | |
| SCHEMBL3600677 | 0.81 | KDM4E (0.46) | GSK3BPRKCBPRKCAPRKCGPRKCZ | |
| SCHEMBL3774109 | 0.76 | GSK3B (0.66) | GSK3BPRKCBPRKCAPRKCGKCNH2 | |
| SCHEMBL4848432 | 0.76 | CDK2 (0.39) | GSK3BPRKCBPRKCAPRKCGCDK2 | |
| SCHEMBL6344642 | 0.74 | PRKCB (0.49) | GSK3BPRKCBPRKCAPRKCGKCNH2 | |
| SCHEMBL5879232 | 0.73 | CCNE2 (0.63) | GSK3BPRKCACDK2CCNE2CDK4 | |
| SCHEMBL29504831 | 0.73 | CCNE2 (0.63) | GSK3BPRKCACDK2CCNE2CDK4 | |
| Hydrochloric Acid SCHEMBL29664072 | 0.72 | CCNE2 (0.61) | GSK3BPRKCACDK2CCNE2CDK4 | |
| SCHEMBL6347654 | 0.71 | GSK3B (0.41) | GSK3BPRKCBPRKCAPRKCGKCNH2 | |
| SCHEMBL6098330 | 0.69 | L3MBTL1 (0.62) | KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6849643-B2 | Indazolyl-substituted pyrroline compounds as kinase inhibitors | ORTHO-MCNEIL PHARMACEUTICAL, INC. (US) | 2005-02-01 | — | — | US | disclosed |