Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.46 |
| ▸ | HPGD | P15428 | 2/20 | 0.46 |
| ▸ | BACE1 | P56817 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 2/20 | 0.42 |
| ▸ | ADRA2C | P18825 | 2/20 | 0.42 |
| ▸ | DPP4 | P27487 | 1/20 | 0.42 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.41 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.40 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.40 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.40 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6350964 | 0.84 | L3MBTL1 (0.42) | KDM4EALDH1A1HPGDTSHRDPP4 | |
| SCHEMBL28467589 | 0.81 | ALDH1A1 (0.63) | HSD17B10KDM4EALDH1A1HPGDBACE1 | |
| SCHEMBL6346667 | 0.77 | TDP1 (0.46) | HSD17B10KDM4EALDH1A1HPGDTSHR | |
| SCHEMBL27670029 | 0.76 | DPP4 (0.60) | HSD17B10ALDH1A1HPGDDPP4LOXL2 | |
| Hydrogen Sulfide SCHEMBL27639876 | 0.74 | DPP4 (0.58) | HSD17B10ALDH1A1HPGDDPP4LOXL2 | |
| SCHEMBL6344376 | 0.74 | DPP4 (0.42) | ALDH1A1ADRA2CDPP4TAAR1CYP2D6 | |
| SCHEMBL6344957 | 0.74 | HPGD (0.58) | HSD17B10KDM4EALDH1A1HPGDBACE1 | |
| SCHEMBL21507732 | 0.74 | ALDH1A1 (0.55) | HSD17B10KDM4EALDH1A1HPGDTSHR | |
| SCHEMBL6344385 | 0.73 | DPP4 (0.43) | KDM4EALDH1A1HPGDDPP4MEN1 | |
| SCHEMBL4571036 | 0.72 | HSD17B10 (0.71) | HSD17B10KDM4EALDH1A1HPGDBACE1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050075352-A1 | 3,4-Dihydro-(1H)-quinazolin-2-ones and their use as CSBP/p38 kinase inhibitors | SMITHKLINE BEECHAM CORPORATION | 2005-04-07 | — | — | US | disclosed |
| US-6759410-B1 | CYTOKINE SUPPRESSIVE ANTIINFLAMMATORIES | SMITHLINE BEECHAM CORPORATION | 2004-07-06 | — | — | US | disclosed |
| EP-1248624-A4 | 3,4-DIHYDRO-(1H)-QUINAZOLIN-2-ONES AND THEIR USE AS CSBP/p38 KINASE INHIBITORS | SMITHKLINE BEECHAM CORP (US) | 2003-01-22 | — | — | EP | disclosed |
| EP-1248624-A1 | 3,4-DIHYDRO-(1H)-QUINAZOLIN-2-ONES AND THEIR USE AS CSBP/p38 KINASE INHIBITORS | SmithKline Beecham Corporation (US) | 2002-10-16 | — | — | EP | disclosed |
| WO-2001037837-A1 | 3,4-DIHYDRO-(1H)-QUINAZOLIN-2-ONES AND THEIR USE AS CSBP/p38 KINASE INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 2001-05-31 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050075352-A1 | 3,4-Dihydro-(1H)-quinazolin-2-ones and their use as CSBP/p38 kinase inhibitors | MAPKAPK2, MAPKAPK3, CREBBP | HSD17B10 4128/4885KDM4E 3076/4885ALDH1A1 4001/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.