Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.42 |
| ▸ | F7 | P08709 | 3/20 | 0.41 |
| ▸ | ADRA1B | P35368 | 3/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | NPC1 | O15118 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | RAB9A | P51151 | 2/20 | 0.41 |
| ▸ | KDM1A | O60341 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | HTR1A | P08908 | 1/20 | 0.41 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.41 |
| ▸ | CYP2C8 | P10632 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | IDO1 | P14902 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6344769 | 0.84 | HSD17B10 (0.46) | MEN1KMT2AALDH1A1CYP1A2HTR1A | |
| SCHEMBL17738673 | 0.81 | L3MBTL1 (0.44) | L3MBTL1MEN1KMT2ANPC1ALDH1A1 | |
| SCHEMBL6346667 | 0.74 | TDP1 (0.46) | L3MBTL1MEN1KMT2AALDH1A1LMNA | |
| SCHEMBL27670029 | 0.74 | DPP4 (0.60) | ALDH1A1RAB9ACYP3A4CYP2C9CYP2C19 | |
| Hydrogen Sulfide SCHEMBL27639876 | 0.72 | DPP4 (0.58) | ALDH1A1RAB9ACYP3A4CYP2C9CYP2C19 | |
| SCHEMBL6344376 | 0.72 | DPP4 (0.42) | F7ADRA1BALDH1A1CYP3A4ADRA2A | |
| SCHEMBL6344385 | 0.71 | DPP4 (0.43) | L3MBTL1MEN1KMT2ANPC1ALDH1A1 | |
| SCHEMBL6366938 | 0.70 | RAB9A (0.61) | L3MBTL1MEN1KMT2ANPC1ALDH1A1 | |
| SCHEMBL3047149 | 0.70 | L3MBTL1 (0.53) | L3MBTL1MEN1KMT2ANPC1ALDH1A1 | |
| SCHEMBL6344696 | 0.69 | DPP4 (0.55) | SMN1; SMN2DPP4TAAR1LOXL2HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050075352-A1 | 3,4-Dihydro-(1H)-quinazolin-2-ones and their use as CSBP/p38 kinase inhibitors | SMITHKLINE BEECHAM CORPORATION | 2005-04-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050075352-A1 | 3,4-Dihydro-(1H)-quinazolin-2-ones and their use as CSBP/p38 kinase inhibitors | MAPKAPK2, MAPKAPK3, CREBBP | L3MBTL1 2163/4885F7 4878/4885ADRA1B 891/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.