Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CNR2 | P34972 | 2/20 | 0.53 |
| ▸ | CYSLTR2 | Q9NS75 | 3/20 | 0.49 |
| ▸ | CYSLTR1 | Q9Y271 | 3/20 | 0.49 |
| ▸ | PTGDR2 | Q9Y5Y4 | 3/20 | 0.49 |
| ▸ | GAA | P10253 | 1/20 | 0.49 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.46 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.46 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.46 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.46 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.46 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.46 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.46 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.46 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.46 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.46 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.45 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7368226 | 0.95 | CNR2 (0.57) | CNR2CYSLTR2CYSLTR1PTGDR2GAA | |
| SCHEMBL7012021 | 0.86 | MAPT (0.45) | CYSLTR2CYSLTR1PTGDR2HDAC3HDAC4 | |
| SCHEMBL1269611 | 0.82 | MEN1 (0.59) | GAAKMT2AMAPTMEN1PRNP | |
| SCHEMBL3169884 | 0.81 | MTNR1B (0.55) | GAA | |
| SCHEMBL415480 | 0.81 | ALDH1A1 (0.55) | PTGDR2KMT2AMAPTCYP3A4CYP2C9 | |
| SCHEMBL20545557 | 0.81 | CNR2 (0.60) | CNR2HDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL3168541 | 0.81 | PTGDR2 (0.44) | CYSLTR2CYSLTR1PTGDR2KMT2AMAPT | |
| SCHEMBL7632059 | 0.80 | CYSLTR2 (0.64) | CYSLTR2CYSLTR1GAAHDAC1KMT2A | |
| SCHEMBL7078818 | 0.80 | ALDH1A1 (0.54) | GAAHDAC3HDAC4HDAC1HDAC7 | |
| Naphthalene SCHEMBL28059486 | 0.80 | CYP4F2 (0.63) | CYSLTR2CYSLTR1GAACYP3A4CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6878736-B1 | Histamine H3 receptor ligands | JAMES BLACK FOUNDATION LIMITED (GB) | 2005-04-12 | — | — | US | disclosed |
| EP-1056733-A1 | HISTAMINE H3 RECEPTOR LIGANDS | JAMES BLACK FOUNDATION LIMITED (GB) | 2000-12-06 | — | — | EP | disclosed |
| WO-1999042458-A1 | HISTAMINE H3 RECEPTOR LIGANDS | JAMES BLACK FOUNDATION LIMITED (GB) | 1999-08-26 | — | — | WO | disclosed |