Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIN2D | O15399 | 1/20 | 0.59 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.59 |
| ▸ | GRIN2C | Q14957 | 1/20 | 0.59 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.54 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.54 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.54 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.51 |
| ▸ | MEN1 | O00255 | 3/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.50 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.50 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.49 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.49 |
| ▸ | HPGD | P15428 | 3/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | PARP1 | P09874 | 2/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.46 |
| ▸ | GLA | P06280 | 1/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.46 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.44 |
| ▸ | TTR | P02766 | 2/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10081747 | 0.90 | GRIN2D (0.68) | GRIN2DGRIN2AGRIN2CALDH1A1CYP1A2 | |
| SCHEMBL10080474 | 0.88 | GRIN2D (0.53) | GRIN2DGRIN2AGRIN2CALDH1A1CYP1A2 | |
| SCHEMBL15439625 | 0.86 | GRIN2D (0.67) | GRIN2DGRIN2AGRIN2CALDH1A1CYP1A2 | |
| SCHEMBL31742339 | 0.86 | GRIN2D (0.67) | GRIN2DGRIN2AGRIN2CALDH1A1CYP1A2 | |
| SCHEMBL10484184 | 0.86 | GRIN2D (0.67) | GRIN2DGRIN2AGRIN2CALDH1A1CYP1A2 | |
| SCHEMBL10484311 | 0.82 | ALDH1A1 (0.68) | GRIN2DGRIN2AGRIN2CALDH1A1CYP1A2 | |
| SCHEMBL2469905 | 0.82 | GRIN2D (0.66) | GRIN2DGRIN2AGRIN2CALDH1A1CYP1A2 | |
| SCHEMBL2469662 | 0.80 | ALDH1A1 (0.70) | GRIN2DGRIN2AGRIN2CALDH1A1CYP1A2 | |
| SCHEMBL10012830 | 0.80 | GRIN2D (0.61) | GRIN2DGRIN2AGRIN2CALDH1A1PTPN1 | |
| SCHEMBL2343264 | 0.80 | GRIN2D (0.61) | GRIN2DGRIN2AGRIN2CALDH1A1PTPN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6916816-B2 | Phenanthryl piperazinyl dicarboxylic acids as selective NMDA receptor modulating agents | THE BOARD OF REGENTS OF THE UNIVERSITY OF NEBRASKA (US) | 2005-07-12 | — | — | US | disclosed |
| EP-1244638-B1 | PHENANTHRYL PIPERAZINYL DICARBOXYLIC ACIDS AS SELECTIVE NMDA RECEPTOR MODULATING AGENTS | UNIV BRISTOL (GB) | 2004-05-12 | — | — | EP | disclosed |
| US-20030078237-A1 | Phenanthryl piperazinyl dicarboxylic acids as selective nmda receptor modulating agents | US ARMY, SECRETARY OF THE ARMY | 2003-04-24 | — | — | US | disclosed |
| EP-1244638-A2 | PHENANTHRYL PIPERAZINYL DICARBOXYLIC ACIDS AS SELECTIVE NMDA RECEPTOR MODULATING AGENTS | UNIVERSITY OF NEBRASKA BOARD OF REGENTS (US) | 2002-10-02 | — | — | EP | disclosed |
| WO-2001044205-A2 | PHENANTHRYL PIPERAZINYL DICARBOXYLIC ACIDS AS SELECTIVE NMDA RECEPTOR MODULATING AGENTS | UNIVERSITY OF NEBRASKA BOARD OF REGENTS (US) | 2001-06-21 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030078237-A1 | Phenanthryl piperazinyl dicarboxylic acids as selective nmda receptor modulating agents | GRIK2, GRIK3, GRIK5 | GRIN2D 13/4885GRIN2A 8/4885GRIN2C 7/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.