SCHEMBL6345915

SCHEMBL6345915

Cn1ccnc1[Si](C)(C)C

nearest known ligand 0.48

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
LPO P22079 1/20 0.48
ALDH1A1 P00352 2/20 0.35
HPGD P15428 1/20 0.35
HSD17B10 Q99714 1/20 0.35
KMT2A Q03164 4/20 0.34
KDM4E B2RXH2 2/20 0.34
HTT P42858 1/20 0.34
FDPS P14324 2/20 0.33
MEN1 O00255 2/20 0.32
BRD4 O60885 1/20 0.32
CHRNB2 P17787 1/20 0.32
CHRNA4 P43681 1/20 0.32
POLB P06746 1/20 0.30
CYP2D6 P10635 1/20 0.30
NPC1 O15118 1/20 0.30
PKM P14618 1/20 0.30
RAB9A P51151 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6829172 0.97 LPO (0.46) LPOALDH1A1HPGDHSD17B10KMT2A
SCHEMBL8089847 0.77 LPO (0.41) LPOALDH1A1HPGDHSD17B10KMT2A
SCHEMBL8089840 0.77 LPO (0.41) LPOALDH1A1HPGDHSD17B10KMT2A
SCHEMBL8084747 0.77 LPO (0.41) LPOALDH1A1HPGDHSD17B10KMT2A
SCHEMBL5722623 0.77 LPO (0.41) LPOALDH1A1HPGDHSD17B10KMT2A
SCHEMBL8076693 0.73 LPO (0.43) LPOALDH1A1HSD17B10KMT2AKDM4E
SCHEMBL5093089 0.73 LPO (0.43) LPOALDH1A1KMT2AKDM4EHTT
SCHEMBL27769632 0.73 LPO (0.43) LPOKMT2AKDM4EHTTFDPS
SCHEMBL8076701 0.72 LPO (0.38) LPOKDM4EHTTFDPSBRD4
SCHEMBL8088201 0.71 LPO (0.36) LPOALDH1A1HSD17B10KMT2AKDM4E

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20240203727-A1 METHOD OF DEPOSITING SILICON-BASED MATERIAL AND PRECURSORS FOR THE SAME ASM IP HOLDING B.V. (NL) 2024-06-20 US disclosed
CN-118207515-A Method for depositing silicon-based materials and precursors thereof ASM IP私人控股有限公司 2024-06-18 CN disclosed
US-6951948-B2 Method for synthesis of substituted azole libraries ORTHO-MCNEIL PHARMACEUTICAL, INC. (US) 2005-10-04 US disclosed
US-6683191-B2 PREPARING A AZOLE COMPOUND ON A SOLID SUPPORT RESIN, CLEAVING THE COMPOUND FROM THE SOLID SUPPORT RESIN BY NUCLEOPHILIC SUBSTITUTION TO FURTHER SUBSTITUTING BY ALKYLATION REACTION ORTHO-MCNEIL PHARMACEUTICALS, INC. 2004-01-27 US disclosed
US-20020077483-A1 Method for synthesis of substituted azole libraries ORTHO-MCNEIL PHARMACEUTICAL, INC. 2002-06-20 US disclosed
US-20020042520-A1 Method for synthesis of substituted azole libraries ORTHO-MCNEIL PHARMACEUTICALS, INC. 2002-04-11 US disclosed
WO-2001094317-A2 METHOD FOR SYNTHESIS OF SUBSTITUTED AZOLE LIBRARIES ORTHO-MCNEIL PHARMACEUTICAL, INC. (US) 2001-12-13 WO disclosed
WO-2001094318-A2 METHOD FOR SYNTHESIS OF SUBSTITUTED AZOLE LIBRARIES ORTHO-MCNEIL PHARMACEUTICAL, INC. (US) 2001-12-13 WO disclosed
EP-1050536-A2 2-(Benz-)Imidazol-, 2-(Benz-)Oxazol- or 2-(Benz-)Thiazol-substituted Silanes Wacker-Chemie GmbH (DE) 2000-11-08 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20020077483-A1 Method for synthesis of substituted azole libraries CYP51A1, LSS, CYP2F1 LPO 3948/4885ALDH1A1 711/4885HPGD 1787/4885
US-20020042520-A1 Method for synthesis of substituted azole libraries CYP51A1, LSS, CYP2F1 LPO 3948/4885ALDH1A1 711/4885HPGD 1787/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.