SCHEMBL8089840

SCHEMBL8089840

CC(C)[Si](C)(C)c1nccn1C

nearest known ligand 0.41

Predicted protein targets (top 11)

geneUniProtsupporting neighboursconfidence
LPO P22079 1/20 0.41
CHRNB2 P17787 1/20 0.35
CHRNA4 P43681 1/20 0.35
KDM4E B2RXH2 1/20 0.34
FDPS P14324 1/20 0.33
ALDH1A1 P00352 1/20 0.32
HPGD P15428 1/20 0.32
HSD17B10 Q99714 1/20 0.32
KMT2A Q03164 1/20 0.31
HTT P42858 1/20 0.31
CYP2D6 P10635 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8089847 0.83 LPO (0.41) LPOCHRNB2CHRNA4KDM4EFDPS
SCHEMBL8076693 0.80 LPO (0.43) LPOCHRNB2CHRNA4KDM4EFDPS
SCHEMBL6345915 0.77 LPO (0.48) LPOCHRNB2CHRNA4KDM4EFDPS
SCHEMBL6829172 0.75 LPO (0.46) LPOCHRNB2CHRNA4KDM4EFDPS
SCHEMBL8076701 0.74 LPO (0.38) LPOCHRNB2CHRNA4KDM4EFDPS
SCHEMBL8088201 0.72 LPO (0.36) LPOCHRNB2CHRNA4KDM4EFDPS
SCHEMBL4065142 0.70 KDM4E (0.50) LPOCHRNB2CHRNA4KDM4EFDPS
SCHEMBL8088192 0.70 KDM4E (0.42) LPOKDM4EKMT2ACYP2D6
SCHEMBL8084747 0.70 LPO (0.41) LPOKDM4EFDPSALDH1A1HPGD
SCHEMBL5722623 0.70 LPO (0.41) LPOKDM4EFDPSALDH1A1HPGD

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1050536-A2 2-(Benz-)Imidazol-, 2-(Benz-)Oxazol- or 2-(Benz-)Thiazol-substituted Silanes Wacker-Chemie GmbH (DE) 2000-11-08 EP disclosed