Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | SLC1A3 | P43003 | 2/20 | 0.43 |
| ▸ | SLC1A2 | P43004 | 2/20 | 0.43 |
| ▸ | SLC1A1 | P43005 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | LTA4H | P09960 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | PSMB5 | P28074 | 1/20 | 0.41 |
| ▸ | CTSK | P43235 | 2/20 | 0.40 |
| ▸ | MMP9 | P14780 | 1/20 | 0.40 |
| ▸ | MMP8 | P22894 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6354865 | 0.93 | ALDH1A1 (0.51) | ALDH1A1NPC1RAB9ASMN1; SMN2SLC1A3 | |
| SCHEMBL18381513 | 0.81 | SLC1A3 (0.53) | ALDH1A1NPC1RAB9ASLC1A3SLC1A2 | |
| SCHEMBL26963671 | 0.81 | SLC1A3 (0.53) | ALDH1A1NPC1RAB9ASLC1A3SLC1A2 | |
| SCHEMBL376695 | 0.81 | SLC1A3 (0.53) | ALDH1A1NPC1RAB9ASLC1A3SLC1A2 | |
| SCHEMBL583986 | 0.80 | ALDH1A1 (0.49) | ALDH1A1NPC1RAB9ASMN1; SMN2SLC1A3 | |
| SCHEMBL583985 | 0.80 | ALDH1A1 (0.49) | ALDH1A1NPC1RAB9ASMN1; SMN2SLC1A3 | |
| SCHEMBL2821271 | 0.80 | ALDH1A1 (0.49) | ALDH1A1NPC1RAB9ASMN1; SMN2SLC1A3 | |
| SCHEMBL14336343 | 0.79 | LTA4H (0.48) | ALDH1A1NPC1RAB9ASMN1; SMN2SLC1A3 | |
| SCHEMBL13555325 | 0.79 | LTA4H (0.48) | ALDH1A1NPC1RAB9ASMN1; SMN2SLC1A3 | |
| SCHEMBL12848459 | 0.77 | PSMB5 (0.48) | ALDH1A1NPC1RAB9ASLC1A3SLC1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6894047-B2 | Triazine compounds useful as sorbitol dehydrogenase inhibitors | PFIZER INC. (US) | 2005-05-17 | — | — | US | disclosed |
| US-20030004166-A1 | Novel triazine compounds useful as sorbitol dehydrogenase inhibitors | PFIZER INC. | 2003-01-02 | — | — | US | disclosed |
| EP-1247809-A2 | Triazine compounds useful as sorbitol dehydrogenase inhibitors | Pfizer Products Inc. (US) | 2002-10-09 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030004166-A1 | Novel triazine compounds useful as sorbitol dehydrogenase inhibitors | SLC5A1, SLC5A2, ADH5 | ALDH1A1 36/4885NPC1 454/4885RAB9A 4187/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.