SCHEMBL63468

SCHEMBL63468

FC(F)(F)c1ccc(C(F)(F)F)cc1

nearest known ligand 0.67

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 1/20 0.67
TSHR P16473 1/20 0.67
KIF11 P52732 6/20 0.61
TRPV6 Q9H1D0 2/20 0.58
CES2 O00748 1/20 0.58
CES1 P23141 1/20 0.58
ORAI1 Q96D31 1/20 0.58
ORAI2 Q96SN7 1/20 0.58
ORAI3 Q9BRQ5 1/20 0.58
MGLL Q99685 1/20 0.58
TAAR1 Q96RJ0 1/20 0.52
EPHX2 P34913 1/20 0.50
HTR3E A5X5Y0 1/20 0.50
HTR3B O95264 1/20 0.50
PLAU P00749 1/20 0.50
HTR3A P46098 1/20 0.50
HTR3D Q70Z44 1/20 0.50
HTR3C Q8WXA8 1/20 0.50
IDO1 P14902 1/20 0.50

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Iodide SCHEMBL29093539 0.92 ALDH1A1 (0.59) ALDH1A1TSHRKIF11TRPV6CES2
Bromide SCHEMBL29093544 0.92 ALDH1A1 (0.59) ALDH1A1TSHRKIF11TRPV6CES2
SCHEMBL13410633 0.89 KIF11 (0.78) ALDH1A1TSHRKIF11TRPV6CES2
SCHEMBL197238 0.89 KIF11 (0.78) ALDH1A1TSHRKIF11TRPV6CES2
SCHEMBL16626100 0.89 ALDH1A1 (0.56) ALDH1A1TSHRKIF11TRPV6CES2
SCHEMBL29914837 0.89 KIF11 (0.78) ALDH1A1TSHRKIF11TRPV6CES2
SCHEMBL13205250 0.86 ALDH1A1 (0.53) ALDH1A1TSHRKIF11TRPV6CES2
SCHEMBL677817 0.86 ALDH1A1 (0.53) ALDH1A1TSHRKIF11TRPV6CES2
SCHEMBL168026 0.86 ALDH1A1 (0.53) ALDH1A1TSHRKIF11TRPV6CES2
SCHEMBL11239014 0.86 ALDH1A1 (0.53) ALDH1A1TSHRKIF11TRPV6CES2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1899 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-12122935-B2 Curable organopolysiloxane composition for forming film and production method for organopolysiloxane cured product film DOW TORAY CO., LTD. (JP) 2024-10-22 US claimed
US-11969752-B2 Organic polymer film and manufacturing method thereof FENG CHIA UNIVERSITY (TW) 2024-04-30 US claimed
CN-117700457-A Electrochromic compound, preparation method and application 北京大学深圳研究生院 2024-03-15 CN claimed
CN-117199535-A Electrolyte, electrochemical device and electronic device 远景睿泰动力技术(上海)有限公司 2023-12-08 CN claimed
CN-115873039-A Method for preparing alkoxy (pentafluoro) cyclotriphosphazene by one-pot method 浙江蓝天环保高科技股份有限公司 2023-03-31 CN claimed
CN-115725573-A Antisense oligonucleotide containing trifluoromethyl base analogue 上海交通大学医学院附属仁济医院 2023-03-03 CN claimed
CN-115725574-A Small interfering RNA (siRNA) containing trifluoromethyl base analog 上海交通大学医学院附属仁济医院 2023-03-03 CN claimed
CN-115197946-A Aptamer containing trifluoromethyl base analogue and application thereof 上海交通大学医学院附属仁济医院 2022-10-18 CN claimed
CN-112500297-B Bis-trifluoromethyl-benzene-substituted asymmetric meta-aromatic diamine monomer and preparation method thereof 常州大学 2022-09-23 CN claimed
US-20220193719-A1 ORGANIC POLYMER FILM AND MANUFACTURING METHOD THEREOF FENG CHIA UNIVERSITY (TW) 2022-06-23 US claimed
US-5968882-A NONFLAMMABLE MIXED SOLVENT COMPRISING COMPLETELY FLUORINATED ORGANIC COMPOUND, PARTIALLY FLUORINATED AROMATIC ORGANIC COMPOUND, UNHALOGENATED HYDROCARBON CANON KABUSHIKI KAISHA (JP) 1999-10-19 US claimed
US-5945155-A Low dielectric constant amorphous fluorinated carbon and method of preparation INTERNATIONAL BUSINESS MACHINES CORPORATION (US) 1999-08-31 US claimed
US-5942328-A Low dielectric constant amorphous fluorinated carbon and method of preparation INTERNATIONAL BUSINESS MACHINES CORPORATION (US) 1999-08-24 US claimed
US-5942769-A Low dielectric constant amorphous fluorinated carbon and method of preparation INTERNATIONAL BUSINESS MACHINES CORPORATION (US) 1999-08-24 US claimed
US-5362477-A 19F magnetic resonance imaging agents which include a nitroxide moiety MALLINCKRODT MEDICAL, INC. (US) 1994-11-08 US claimed
EP-0587440-A2 Catalyst component for the polymerisation of olefins and process for preparing olefin polymers using same NIPPON OIL COMPANY, LIMITED (JP) 1994-03-16 EP claimed
US-5268202-A Using halogen promoter and metal catalyst RENSSELAER POLYTECHNIC INSTITUTE (US) 1993-12-07 US claimed
US-5177302-A Inclusion Complexes with Substituted Cyclodextrins DIRECTOR-GENERAL, AGENCY OF INDUSTRIAL SCIENCE AND TECHNOLOGY (JP) 1993-01-05 US claimed
US-4849557-A Preparation of trifluoromethyltoluene from halomethylbenzotrifluoride CENTRAL GLASS COMPANY, LIMITED (JP) 1989-07-18 US claimed
US-4079090-A Preparation of trichloromethyl-trifluoro methyl-benzenes BAYER AKTIENGESELLSCHAFT (DT) 1978-03-14 US claimed