Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BCHE | P06276 | 1/20 | 0.38 |
| ▸ | CTSD | P07339 | 3/20 | 0.36 |
| ▸ | FPR2 | P25090 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | PPARG | P37231 | 1/20 | 0.36 |
| ▸ | PPARA | Q07869 | 1/20 | 0.36 |
| ▸ | GPR139 | Q6DWJ6 | 1/20 | 0.36 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.36 |
| ▸ | BACE1 | P56817 | 3/20 | 0.35 |
| ▸ | PSMB8 | P28062 | 2/20 | 0.35 |
| ▸ | CNR2 | P34972 | 1/20 | 0.35 |
| ▸ | ELANE | P08246 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6348393 | 0.92 | POLB (0.38) | BCHEBACE1ALDH1A1 | |
| SCHEMBL6358276 | 0.90 | POLB (0.35) | BCHECTSDBACE1ELANEALDH1A1 | |
| SCHEMBL6348272 | 0.86 | CAPN1 (0.40) | FPR2GPR139ADORA2APSMB8ALDH1A1 | |
| SCHEMBL6348278 | 0.86 | CAPN1 (0.40) | FPR2GPR139ADORA2APSMB8ALDH1A1 | |
| SCHEMBL6354395 | 0.82 | POLB (0.38) | BCHECTSDKMT2ABACE1ALDH1A1 | |
| SCHEMBL6349872 | 0.80 | FPR2 (0.36) | BCHEFPR2KMT2APPARGPPARA | |
| SCHEMBL6350463 | 0.79 | CA9 (0.41) | KMT2AALDH1A1 | |
| SCHEMBL6349895 | 0.78 | ALDH1A1 (0.41) | KMT2APPARGALDH1A1 | |
| SCHEMBL6349893 | 0.78 | ALDH1A1 (0.41) | KMT2APPARGALDH1A1 | |
| SCHEMBL6347128 | 0.78 | POLB (0.39) | ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6960575-B2 | For use as inhibitors of chymase | SANTEN PHARMACEUTICAL CO., LTD. (JP) | 2005-11-01 | — | — | US | disclosed |
| US-6713472-B1 | 2-OXO-1,2,3,4-TETRAHYDROPYRAZINE DERIVATIVES; CHYMASE INHIBITORS | SANTEN PHARMACEUTICAL CO., LTD. (JP) | 2004-03-30 | — | — | US | disclosed |