Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
| ▸ | BACE1 | P56817 | 3/20 | 0.34 |
| ▸ | CTSD | P07339 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.34 |
| ▸ | OXTR | P30559 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | CMA1 | P23946 | 3/20 | 0.33 |
| ▸ | GPR34 | Q9UPC5 | 1/20 | 0.33 |
| ▸ | CTRC | Q99895 | 1/20 | 0.33 |
| ▸ | PYGL | P06737 | 1/20 | 0.33 |
| ▸ | BCHE | P06276 | 1/20 | 0.33 |
| ▸ | ELANE | P08246 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6348393 | 0.94 | POLB (0.38) | POLBNPSR1BACE1ALDH1A1PYGL | |
| SCHEMBL6346809 | 0.90 | BCHE (0.38) | BACE1CTSDALDH1A1BCHEELANE | |
| SCHEMBL6351926 | 0.85 | OXTR (0.39) | POLBALDH1A1OXTRCMA1GPR34 | |
| SCHEMBL6351923 | 0.85 | OXTR (0.39) | POLBALDH1A1OXTRCMA1GPR34 | |
| SCHEMBL6354395 | 0.83 | POLB (0.38) | POLBNPSR1BACE1CTSDALDH1A1 | |
| SCHEMBL6347131 | 0.79 | POLB (0.39) | POLBALDH1A1LMNA | |
| SCHEMBL6347128 | 0.79 | POLB (0.39) | POLBALDH1A1LMNA | |
| SCHEMBL6350481 | 0.78 | ALDH1A1 (0.38) | ALDH1A1KDM4E | |
| SCHEMBL6350484 | 0.78 | ALDH1A1 (0.38) | ALDH1A1KDM4E | |
| SCHEMBL6352185 | 0.76 | BACE1 (0.37) | POLBBACE1ALDH1A1PYGLBCHE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6960575-B2 | For use as inhibitors of chymase | SANTEN PHARMACEUTICAL CO., LTD. (JP) | 2005-11-01 | — | — | US | disclosed |
| US-6713472-B1 | 2-OXO-1,2,3,4-TETRAHYDROPYRAZINE DERIVATIVES; CHYMASE INHIBITORS | SANTEN PHARMACEUTICAL CO., LTD. (JP) | 2004-03-30 | — | — | US | disclosed |