Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA1D | P25100 | 4/20 | 0.45 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.42 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | HPGD | P15428 | 2/20 | 0.41 |
| ▸ | GLA | P06280 | 1/20 | 0.41 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 2/20 | 0.39 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9413098 | 0.78 | CYP2C9 (0.45) | ADRA1DTDP1TAAR1POLBLMNA | |
| SCHEMBL559559 | 0.75 | TAAR1 (0.56) | ADRA1DTDP1ALDH1A1HPGDTAAR1 | |
| SCHEMBL28998728 | 0.73 | POLB (0.47) | ADRA1DPTGS1PTGS2TDP1ALDH1A1 | |
| SCHEMBL6947065 | 0.73 | ADRA1D (0.46) | ADRA1DALDH1A1HPGDPOLBALOX5 | |
| SCHEMBL8398705 | 0.72 | POLB (0.54) | PTGS1PTGS2ALDH1A1HPGDGLA | |
| SCHEMBL25290450 | 0.72 | TP53 (0.49) | ADRA1DALDH1A1HPGDPOLBALOX5 | |
| SCHEMBL14812247 | 0.71 | PTGS1 (0.49) | ADRA1DPTGS1PTGS2TDP1ALDH1A1 | |
| SCHEMBL3385419 | 0.69 | MEN1 (0.54) | PTGS1PTGS2ALDH1A1HPGDTAAR1 | |
| SCHEMBL28745656 | 0.69 | ALDH1A1 (0.46) | ADRA1DPTGS1PTGS2ALDH1A1HPGD | |
| SCHEMBL29152299 | 0.69 | PTGS1 (0.51) | PTGS1PTGS2TDP1ALDH1A1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6906093-B2 | Indolinone combinatorial libraries and related products and methods for the treatment of disease | SUGEN, INC. (US) | 2005-06-14 | — | — | US | disclosed |