Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AR | P10275 | 7/20 | 0.46 |
| ▸ | PGR | P06401 | 1/20 | 0.46 |
| ▸ | PPARG | P37231 | 1/20 | 0.39 |
| ▸ | PPARD | Q03181 | 1/20 | 0.39 |
| ▸ | PPARA | Q07869 | 1/20 | 0.39 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL634405 | 0.80 | AR (0.45) | ARPGRPPARGPPARDPPARA | |
| SCHEMBL634753 | 0.79 | PPARG (0.39) | PPARGPPARDPPARA | |
| SCHEMBL633694 | 0.77 | AR (0.59) | ARPGRHDAC1 | |
| SCHEMBL633631 | 0.75 | SMN1; SMN2 (0.49) | ARPGR | |
| SCHEMBL629334 | 0.74 | AR (0.38) | ARPGRPPARGPPARDPPARA | |
| SCHEMBL628964 | 0.73 | AR (0.37) | ARPGRHDAC1 | |
| SCHEMBL629437 | 0.73 | AR (0.37) | ARPGRPPARGPPARDPPARA | |
| SCHEMBL631033 | 0.72 | AR (0.37) | ARPGRPPARGPPARDPPARA | |
| SCHEMBL14735643 | 0.71 | AR (0.40) | ARPGR | |
| SCHEMBL629028 | 0.71 | SMN1; SMN2 (0.45) | ARPGR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2419422-B1 | IMIDAZOLIDINE-2,4-DIONE DERIVATIVES AND USE THEREOF AS A MEDICAMENT | IPSEN PHARMA SAS (FR) | 2014-10-15 | — | — | EP | disclosed |
| US-8624037-B2 | Imidazolidine-2,4-dione derivatives and use thereof as a medicament | IPSEN PHARMA S.A.S. (FR) | 2014-01-07 | — | — | US | disclosed |
| EP-2419422-A1 | IMIDAZOLIDINE-2,4-DIONE DERIVATIVES AND USE THEREOF AS A MEDICAMENT | IPSEN PHARMA S.A.S. (FR) | 2012-02-22 | — | — | EP | disclosed |
| WO-2010119194-A1 | IMIDAZOLIDINE-2,4-DIONE DERIVATIVES AND USE THEREOF AS A MEDICAMENT | IPSEN PHARMA S.A.S. (FR) | 2010-10-21 | — | — | WO | disclosed |