Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARG | P37231 | 1/20 | 0.39 |
| ▸ | PPARD | Q03181 | 1/20 | 0.39 |
| ▸ | PPARA | Q07869 | 1/20 | 0.39 |
| ▸ | GFER | P55789 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.37 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.34 |
| ▸ | APOBEC3A | P31941 | 1/20 | 0.34 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.34 |
| ▸ | FAAH | O00519 | 1/20 | 0.34 |
| ▸ | MGLL | Q99685 | 1/20 | 0.34 |
| ▸ | TP53 | P04637 | 2/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | USP2 | O75604 | 2/20 | 0.32 |
| ▸ | PSMD14 | O00487 | 1/20 | 0.32 |
| ▸ | MMP2 | P08253 | 1/20 | 0.32 |
| ▸ | GRM1 | Q13255 | 1/20 | 0.32 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL634406 | 0.89 | PPARG (0.38) | PPARGPPARDPPARAGFERKMT2A | |
| SCHEMBL634752 | 0.79 | AR (0.46) | PPARGPPARDPPARA | |
| SCHEMBL633869 | 0.76 | AR (0.47) | — | |
| SCHEMBL634102 | 0.68 | AR (0.50) | — | |
| SCHEMBL2091371 | 0.60 | MEN1 (0.71) | KMT2ALMNAMEN1TP53ALDH1A1 | |
| SCHEMBL8048607 | 0.60 | SLC1A3 (0.53) | KMT2AMEN1TP53ALDH1A1GAA | |
| SCHEMBL11118946 | 0.60 | GPR174 (0.59) | KMT2AMEN1TP53ALDH1A1GAA | |
| SCHEMBL7571649 | 0.59 | MGLL (0.72) | LMNAFAAHMGLLALDH1A1GAA | |
| SCHEMBL4830911 | 0.59 | MAPT (0.49) | KMT2ALMNAMEN1TP53ALDH1A1 | |
| Fluoride SCHEMBL11786773 | 0.59 | MEN1 (0.69) | KMT2ALMNAMEN1TP53ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2419422-B1 | IMIDAZOLIDINE-2,4-DIONE DERIVATIVES AND USE THEREOF AS A MEDICAMENT | IPSEN PHARMA SAS (FR) | 2014-10-15 | — | — | EP | disclosed |
| US-8624037-B2 | Imidazolidine-2,4-dione derivatives and use thereof as a medicament | IPSEN PHARMA S.A.S. (FR) | 2014-01-07 | — | — | US | disclosed |
| EP-2419422-A1 | IMIDAZOLIDINE-2,4-DIONE DERIVATIVES AND USE THEREOF AS A MEDICAMENT | IPSEN PHARMA S.A.S. (FR) | 2012-02-22 | — | — | EP | disclosed |
| WO-2010119194-A1 | IMIDAZOLIDINE-2,4-DIONE DERIVATIVES AND USE THEREOF AS A MEDICAMENT | IPSEN PHARMA S.A.S. (FR) | 2010-10-21 | — | — | WO | disclosed |