Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.41 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.40 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.40 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.40 |
| ▸ | MAOA | P21397 | 1/20 | 0.40 |
| ▸ | MAOB | P27338 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 3/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.39 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.38 |
| ▸ | AR | P10275 | 1/20 | 0.37 |
| ▸ | PDE1C | Q14123 | 1/20 | 0.37 |
| ▸ | LDHA | P00338 | 1/20 | 0.37 |
| ▸ | LDHB | P07195 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6343690 | 0.86 | CD274 (0.42) | ALDH1A1HPGDADRA2AADRA2BADRA2C | |
| SCHEMBL19018356 | 0.78 | ADORA1 (0.47) | ALDH1A1HPGDSMN1; SMN2KDM4EMEN1 | |
| SCHEMBL6350962 | 0.73 | ADRA2A (0.40) | ADRA2AADRA2BADRA2CMAOAMAOB | |
| SCHEMBL6342286 | 0.73 | ADORA2A (0.49) | ALDH1A1HPGDSMN1; SMN2KDM4EMEN1 | |
| SCHEMBL18027646 | 0.73 | MEN1 (0.53) | ALDH1A1ADRA2ASMN1; SMN2KDM4EMEN1 | |
| SCHEMBL12679716 | 0.73 | ALDH1A1 (0.52) | ALDH1A1HPGDSMN1; SMN2KDM4EMEN1 | |
| SCHEMBL17267238 | 0.71 | ALDH1A1 (0.45) | ALDH1A1HPGDSMN1; SMN2KDM4EMEN1 | |
| SCHEMBL6344957 | 0.71 | HPGD (0.58) | ALDH1A1HPGDADRA2CSMN1; SMN2KDM4E | |
| SCHEMBL6366941 | 0.69 | MAPT (0.57) | ALDH1A1MAOASMN1; SMN2KDM4EMEN1 | |
| SCHEMBL27532552 | 0.69 | ALDH1A1 (0.43) | ALDH1A1HPGDSMN1; SMN2KDM4EMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050075352-A1 | 3,4-Dihydro-(1H)-quinazolin-2-ones and their use as CSBP/p38 kinase inhibitors | SMITHKLINE BEECHAM CORPORATION | 2005-04-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050075352-A1 | 3,4-Dihydro-(1H)-quinazolin-2-ones and their use as CSBP/p38 kinase inhibitors | MAPKAPK2, MAPKAPK3, CREBBP | ALDH1A1 4001/4885HPGD 3167/4885ALOX5 4866/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.