Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA2A | P08913 | 1/20 | 0.40 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.40 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.40 |
| ▸ | MAOA | P21397 | 1/20 | 0.40 |
| ▸ | MAOB | P27338 | 1/20 | 0.40 |
| ▸ | ATP1A1 | P05023 | 4/20 | 0.40 |
| ▸ | ATP1B1 | P05026 | 4/20 | 0.40 |
| ▸ | ATP1A3 | P13637 | 4/20 | 0.40 |
| ▸ | ATP1B2 | P14415 | 4/20 | 0.40 |
| ▸ | ATP1A2 | P50993 | 4/20 | 0.40 |
| ▸ | ATP1B3 | P54709 | 4/20 | 0.40 |
| ▸ | FXYD2 | P54710 | 4/20 | 0.40 |
| ▸ | ATP1A4 | Q13733 | 4/20 | 0.40 |
| ▸ | TAAR1 | Q96RJ0 | 2/20 | 0.40 |
| ▸ | LDHA | P00338 | 1/20 | 0.39 |
| ▸ | LDHB | P07195 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 4/20 | 0.39 |
| ▸ | HTT | P42858 | 2/20 | 0.39 |
| ▸ | USP2 | O75604 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6344376 | 0.86 | DPP4 (0.42) | ADRA2AADRA2BADRA2CMAOAMAOB | |
| SCHEMBL6350072 | 0.73 | ALDH1A1 (0.43) | ADRA2AADRA2BADRA2CMAOAMAOB | |
| SCHEMBL6346667 | 0.73 | TDP1 (0.46) | TAAR1MAPTHTTLMNAMAPK1 | |
| SCHEMBL18027646 | 0.73 | MEN1 (0.53) | ADRA2ATAAR1HTTLMNAMEN1 | |
| SCHEMBL27670029 | 0.73 | DPP4 (0.60) | TAAR1MAPK1RAB9APDCD1CD274 | |
| SCHEMBL6344385 | 0.73 | DPP4 (0.43) | MAPTHTTLMNAMAPK1MEN1 | |
| Hydrogen Sulfide SCHEMBL27639876 | 0.71 | DPP4 (0.58) | TAAR1MAPK1RAB9APDCD1CD274 | |
| SCHEMBL6344769 | 0.71 | HSD17B10 (0.46) | ADRA2AADRA2BADRA2CMAOAMAOB | |
| SCHEMBL6366941 | 0.69 | MAPT (0.57) | MAOAMAPTHTTLMNAMAPK1 | |
| SCHEMBL6350964 | 0.69 | L3MBTL1 (0.42) | ADRA2AMAOAMAOBTAAR1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050075352-A1 | 3,4-Dihydro-(1H)-quinazolin-2-ones and their use as CSBP/p38 kinase inhibitors | SMITHKLINE BEECHAM CORPORATION | 2005-04-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050075352-A1 | 3,4-Dihydro-(1H)-quinazolin-2-ones and their use as CSBP/p38 kinase inhibitors | MAPKAPK2, MAPKAPK3, CREBBP | ADRA2A 1468/4885ADRA2B 745/4885ADRA2C 918/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.