Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR2 | P41597 | 7/20 | 0.51 |
| ▸ | CCR5 | P51681 | 15/20 | 0.42 |
| ▸ | CCR7 | P32248 | 3/20 | 0.40 |
| ▸ | CXCR3 | P49682 | 3/20 | 0.39 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.39 |
| ▸ | CCR3 | P51677 | 1/20 | 0.39 |
| ▸ | CCR4 | P51679 | 1/20 | 0.39 |
| ▸ | CXCR5 | P32302 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6341780 | 0.92 | CCR2 (0.58) | CCR2CCR5CCR7CXCR3CXCR5 | |
| SCHEMBL6350329 | 0.90 | CCR2 (0.49) | CCR2CCR5CCR7CXCR3HDAC1 | |
| SCHEMBL3459293 | 0.90 | CCR2 (0.59) | CCR2CCR5CCR7CXCR3CXCR5 | |
| SCHEMBL3459294 | 0.90 | CCR2 (0.59) | CCR2CCR5CCR7CXCR3CXCR5 | |
| SCHEMBL3031895 | 0.85 | CCR5 (0.56) | CCR2CCR5CCR7HDAC1CCR3 | |
| SCHEMBL3039360 | 0.84 | CCR5 (0.58) | CCR2CCR5CCR7CCR3CCR4 | |
| SCHEMBL3038089 | 0.83 | CCR5 (0.53) | CCR2CCR5CCR7HDAC1CCR3 | |
| SCHEMBL3040670 | 0.82 | CCR5 (0.55) | CCR2CCR5CCR7CCR3CCR4 | |
| SCHEMBL6342697 | 0.81 | MAPT (0.47) | CCR2CCR5CCR7CCR3CCR4 | |
| SCHEMBL7486829 | 0.81 | CCR5 (0.44) | CCR2CCR5CCR7CXCR3HDAC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6936602-B1 | Benzazepine derivatives, process for the preparation of the same and uses thereof | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 2005-08-30 | — | — | US | disclosed |
| EP-1186604-A1 | BENZAZEPINE DERIVATIVES, PROCESS FOR THE PREPARATION OF THE SAME AND USES THEREOF | Takeda Chemical Industries, Ltd. (JP) | 2002-03-13 | — | — | EP | disclosed |