Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.49 |
| ▸ | ATM | Q13315 | 1/20 | 0.45 |
| ▸ | CTRB1 | P17538 | 2/20 | 0.45 |
| ▸ | CTSB | P07858 | 2/20 | 0.43 |
| ▸ | CTSL | P07711 | 1/20 | 0.43 |
| ▸ | CTSS | P25774 | 1/20 | 0.43 |
| ▸ | CTSK | P43235 | 1/20 | 0.43 |
| ▸ | TACR1 | P25103 | 3/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.42 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.41 |
| ▸ | TSHR | P16473 | 4/20 | 0.41 |
| ▸ | CASP1 | P29466 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7359622 | 0.87 | KLK5 (0.48) | ATMCTSBCTSLCTSSCTSK | |
| SCHEMBL6352237 | 0.86 | TRPM8 (0.45) | TRPM8ATMCTRB1CTSBCTSL | |
| SCHEMBL6349525 | 0.80 | TRPM8 (0.49) | TRPM8ATMCTRB1CTSBCTSL | |
| SCHEMBL8066015 | 0.80 | TRPM8 (0.49) | TRPM8ATMCTRB1CTSBCTSL | |
| SCHEMBL1709149 | 0.78 | PSMB9 (0.55) | TRPM8ATMCTRB1CTSBCTSL | |
| SCHEMBL1709152 | 0.78 | PSMB9 (0.55) | TRPM8ATMCTRB1CTSBCTSL | |
| SCHEMBL12052767 | 0.78 | PSMB9 (0.55) | TRPM8ATMCTRB1CTSBCTSL | |
| SCHEMBL14725144 | 0.78 | PSMB9 (0.55) | TRPM8ATMCTRB1CTSBCTSL | |
| SCHEMBL1701914 | 0.78 | PSMB9 (0.55) | TRPM8ATMCTRB1CTSBCTSL | |
| SCHEMBL17452278 | 0.78 | PSMB9 (0.55) | TRPM8ATMCTRB1CTSBCTSL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6960575-B2 | For use as inhibitors of chymase | SANTEN PHARMACEUTICAL CO., LTD. (JP) | 2005-11-01 | — | — | US | disclosed |
| US-6713472-B1 | 2-OXO-1,2,3,4-TETRAHYDROPYRAZINE DERIVATIVES; CHYMASE INHIBITORS | SANTEN PHARMACEUTICAL CO., LTD. (JP) | 2004-03-30 | — | — | US | disclosed |