Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.45 |
| ▸ | CTRB1 | P17538 | 2/20 | 0.43 |
| ▸ | TACR1 | P25103 | 3/20 | 0.42 |
| ▸ | ATM | Q13315 | 1/20 | 0.41 |
| ▸ | CTSB | P07858 | 2/20 | 0.41 |
| ▸ | ECE1 | P42892 | 1/20 | 0.40 |
| ▸ | CTSL | P07711 | 1/20 | 0.39 |
| ▸ | CTSS | P25774 | 1/20 | 0.39 |
| ▸ | CTSK | P43235 | 1/20 | 0.39 |
| ▸ | SPPL2A | Q8TCT8 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.38 |
| ▸ | TSHR | P16473 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | ACE | P12821 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6350520 | 0.86 | TRPM8 (0.49) | TRPM8CTRB1TACR1ATMCTSB | |
| SCHEMBL6349525 | 0.78 | TRPM8 (0.49) | TRPM8CTRB1TACR1ATMCTSB | |
| SCHEMBL8066015 | 0.78 | TRPM8 (0.49) | TRPM8CTRB1TACR1ATMCTSB | |
| SCHEMBL2736202 | 0.72 | TRPM8 (0.64) | TRPM8CTRB1TACR1ATMCTSB | |
| SCHEMBL2736218 | 0.72 | TRPM8 (0.64) | TRPM8CTRB1TACR1ATMCTSB | |
| SCHEMBL7337287 | 0.72 | TRPM8 (0.64) | TRPM8CTRB1TACR1ATMCTSB | |
| SCHEMBL4949767 | 0.72 | TRPM8 (0.64) | TRPM8CTRB1TACR1ATMCTSB | |
| SCHEMBL9421829 | 0.72 | TRPM8 (0.64) | TRPM8CTRB1TACR1ATMCTSB | |
| SCHEMBL5916913 | 0.72 | TRPM8 (0.64) | TRPM8CTRB1TACR1ATMCTSB | |
| SCHEMBL17452278 | 0.72 | PSMB9 (0.55) | TRPM8CTRB1TACR1ATMCTSB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6960575-B2 | For use as inhibitors of chymase | SANTEN PHARMACEUTICAL CO., LTD. (JP) | 2005-11-01 | — | — | US | disclosed |
| US-6713472-B1 | 2-OXO-1,2,3,4-TETRAHYDROPYRAZINE DERIVATIVES; CHYMASE INHIBITORS | SANTEN PHARMACEUTICAL CO., LTD. (JP) | 2004-03-30 | — | — | US | disclosed |