Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.49 |
| ▸ | CTRB1 | P17538 | 2/20 | 0.47 |
| ▸ | CTSB | P07858 | 5/20 | 0.46 |
| ▸ | ATM | Q13315 | 1/20 | 0.45 |
| ▸ | TACR1 | P25103 | 3/20 | 0.44 |
| ▸ | CTSL | P07711 | 3/20 | 0.43 |
| ▸ | CTSK | P43235 | 5/20 | 0.43 |
| ▸ | CTSS | P25774 | 4/20 | 0.43 |
| ▸ | SPPL2A | Q8TCT8 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6349525 | 1.00 | TRPM8 (0.49) | TRPM8CTRB1CTSBATMTACR1 | |
| SCHEMBL6350520 | 0.80 | TRPM8 (0.49) | TRPM8CTRB1CTSBATMTACR1 | |
| SCHEMBL6352237 | 0.78 | TRPM8 (0.45) | TRPM8CTRB1CTSBATMTACR1 | |
| SCHEMBL6349588 | 0.78 | TRPM8 (0.49) | TRPM8CTRB1CTSBATMTACR1 | |
| SCHEMBL5916913 | 0.76 | TRPM8 (0.64) | TRPM8CTRB1CTSBATMTACR1 | |
| SCHEMBL2736218 | 0.76 | TRPM8 (0.64) | TRPM8CTRB1CTSBATMTACR1 | |
| SCHEMBL4949767 | 0.76 | TRPM8 (0.64) | TRPM8CTRB1CTSBATMTACR1 | |
| SCHEMBL9421829 | 0.76 | TRPM8 (0.64) | TRPM8CTRB1CTSBATMTACR1 | |
| SCHEMBL7337287 | 0.76 | TRPM8 (0.64) | TRPM8CTRB1CTSBATMTACR1 | |
| SCHEMBL2736202 | 0.76 | TRPM8 (0.64) | TRPM8CTRB1CTSBATMTACR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6080738-A | USEFUL AS CHYMASE INHIBITORS AND CAN BE USED FOR THE PROPHYLAXIS AND TREATMENT OF VARIOUS DISEASES CAUSED BY CHYMASE, SUCH AS THOSE CAUSED BY ANGIOTENSIN II | YOSHITOMI PHARMACEUTICALS INDUSTRIES, LTD. (JP) | 2000-06-27 | — | — | US | disclosed |
| EP-0940400-A1 | NOVEL HETEROCYCLIC AMIDE COMPOUNDS AND MEDICINAL USES THEREOF | YOSHITOMI PHARMACEUTICAL INDUSTRIES, LTD. (JP) | 1999-09-08 | — | — | EP | disclosed |