Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 8/20 | 0.48 |
| ▸ | TP53 | P04637 | 2/20 | 0.47 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 2/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1495920 | 0.85 | MAPT (0.50) | MAPTTP53CYP2C9POLB | |
| SCHEMBL4868711 | 0.78 | MAPT (0.43) | MAPTTP53CYP2C9POLB | |
| SCHEMBL31259600 | 0.76 | CYP2C9 (0.48) | MAPTTP53CYP2C9POLB | |
| SCHEMBL1495972 | 0.75 | KMT2A (0.47) | MAPTTP53 | |
| SCHEMBL26005660 | 0.74 | MAPT (0.63) | MAPTTP53POLB | |
| SCHEMBL13273471 | 0.73 | KCNN4 (0.51) | MAPTCYP2C9POLB | |
| SCHEMBL13302143 | 0.71 | MAPT (0.54) | MAPTPOLB | |
| SCHEMBL16794469 | 0.71 | HTR6 (0.50) | MAPTTP53POLB | |
| SCHEMBL29676616 | 0.71 | HTR6 (0.50) | MAPTTP53POLB | |
| SCHEMBL6339486 | 0.71 | MAPT (0.48) | MAPTTP53CYP2C9POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6936602-B1 | Benzazepine derivatives, process for the preparation of the same and uses thereof | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 2005-08-30 | — | — | US | disclosed |
| EP-1186604-A1 | BENZAZEPINE DERIVATIVES, PROCESS FOR THE PREPARATION OF THE SAME AND USES THEREOF | Takeda Chemical Industries, Ltd. (JP) | 2002-03-13 | — | — | EP | disclosed |