Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOA | P21397 | 7/20 | 1.00 |
| ▸ | MAOB | P27338 | 5/20 | 1.00 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.61 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.61 |
| ▸ | HPGD | P15428 | 2/20 | 0.61 |
| ▸ | TYMS | P04818 | 1/20 | 0.61 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.61 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.61 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.61 |
| ▸ | MAPT | P10636 | 4/20 | 0.55 |
| ▸ | LMNA | P02545 | 2/20 | 0.55 |
| ▸ | GAA | P10253 | 2/20 | 0.55 |
| ▸ | RAB9A | P51151 | 2/20 | 0.50 |
| ▸ | RECQL | P46063 | 1/20 | 0.48 |
| ▸ | PRF1 | P14222 | 1/20 | 0.48 |
| ▸ | CES1 | P23141 | 2/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11522370 | 1.00 | MAOA (1.00) | MAOAMAOBALDH1A1KDM4EHPGD | |
| SCHEMBL6903786 | 1.00 | MAOA (1.00) | MAOAMAOBALDH1A1KDM4EHPGD | |
| SCHEMBL22284 | 1.00 | MAOA (1.00) | MAOAMAOBALDH1A1KDM4EHPGD | |
| SCHEMBL29448271 | 1.00 | MAOA (1.00) | MAOAMAOBALDH1A1KDM4EHPGD | |
| Water SCHEMBL11007472 | 0.98 | MAOA (0.95) | MAOAMAOBALDH1A1KDM4EHPGD | |
| Methane SCHEMBL11197593 | 0.98 | MAOA (0.95) | MAOAMAOBALDH1A1KDM4EHPGD | |
| Fluoride SCHEMBL8592140 | 0.98 | MAOA (0.95) | MAOAMAOBALDH1A1KDM4EHPGD | |
| Benzene SCHEMBL18492989 | 0.98 | MAOA (0.95) | MAOAMAOBALDH1A1KDM4EHPGD | |
| Hydrochloric Acid SCHEMBL11215152 | 0.98 | MAOA (0.95) | MAOAMAOBALDH1A1KDM4EHPGD | |
| SCHEMBL12540036 | 0.98 | MAOA (0.95) | MAOAMAOBALDH1A1KDM4EHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 17 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5162573-A | Anticonvulsant, antiepileptic agent | CHIESI FARMACEUTICI S.P.A. (IT) | 1992-11-10 | — | — | US | claimed |
| EP-0295100-A1 | Methoxymethyl compounds | FARMITALIA CARLO ERBA S.r.l. (IT) | 1988-12-14 | — | — | EP | claimed |
| US-20150119346-A1 | GLYCOSYLATED VALPROIC ACID ANALOGS AND USES THEREOF | Chromatin Technologies | 2015-04-30 | — | — | US | disclosed |
| US-8921533-B2 | Glycosylated valproic acid analogs and uses thereof | Chromatin Technologies (US) | 2014-12-30 | — | — | US | disclosed |
| US-20130029924-A1 | GLYCOSYLATED VALPROIC ACID ANALOGS AND USES THEREOF | Chromatin Technologies (US) | 2013-01-31 | — | — | US | disclosed |
| US-20050090498-A1 | 3-Quinolin-2(1h)-ylideneindolin-2-one derivative | YAMANOUCHI PHARMACEUTICAL CO., LTD. (JP) | 2005-04-28 | — | — | US | disclosed |
| EP-1396490-A1 | 3-QUINOLINE-2-(1H)-YLIDENEINDOLIN-2-ONE DERIVATIVES | YAMANOUCHI PHARMACEUTICAL CO. LTD. (JP) | 2004-03-10 | — | — | EP | disclosed |
| US-5162573-A | Anticonvulsant, antiepileptic agent | CHIESI FARMACEUTICI S.P.A. (IT) | 1992-11-10 | — | — | US | disclosed |
| EP-0250997-B1 | VALPROIC AND (E)-2-VALPROENOIC ACID DERIVATIVES, PROCESSES FOR THE PREPARATION THEREOF AND PHARMACEUTICAL COMPOSITIONS THEREFROM | CHIESI FARMACEUTICI S.p.A. (IT) | 1992-04-15 | — | — | EP | disclosed |
| EP-0250997-A2 | Valproic and (E)-2-valproenoic acid derivatives, processes for the preparation thereof and pharmaceutical compositions therefrom | CHIESI FARMACEUTICI S.p.A. (IT) | 1988-01-07 | — | — | EP | disclosed |
| EP-0018155-A2 | Novel cephalosporin compounds, a process for the preparation thereof, pharmaceutical compositions containing the same and the use thereof as a therapeutic agent against a microorganism | NOVO NORDISK A/S (DK) | 1980-10-29 | — | — | EP | disclosed |
| EP-0009008-A2 | Cephalosporin derivatives, process for their preparation and pharmaceutical compositions containing them | CIBA-GEIGY AG (CH) | 1980-03-19 | — | — | EP | disclosed |
| US-4035391-A | Phthalide and naphthalide derivatives | POLAROID CORPORATION (US) | 1977-07-12 | — | — | US | disclosed |
| US-4032545-A | PHTHALIDES AND NAPHTHALIDES | POLAROID CORPORATION (US) | 1977-06-28 | — | — | US | disclosed |
| US-4001278-A | INDOLE PHTHALIDES AND NAPHTHALIDES | POLAROID CORPORATION (US) | 1977-01-04 | — | — | US | disclosed |
| US-4001275-A | INDOLE DEHYDRO PHTHALIDES AND NAPHTHALIDES | POLAROID CORPORATION (US) | 1977-01-04 | — | — | US | disclosed |
| US-3941807-A | Indole dehydro phthalides and naphthalides | POLAROID CORPORATION (US) | 1976-03-02 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050090498-A1 | 3-Quinolin-2(1h)-ylideneindolin-2-one derivative | KDR, FLT4, FLT1 | MAOA 4445/4885MAOB 4555/4885ALDH1A1 1986/4885 |
| US-20130029924-A1 | GLYCOSYLATED VALPROIC ACID ANALOGS AND USES THEREOF | HDAC3, VGF, HDAC1 | MAOA 707/4885MAOB 1079/4885ALDH1A1 97/4885 |
| US-20150119346-A1 | GLYCOSYLATED VALPROIC ACID ANALOGS AND USES THEREOF | HDAC3, VGF, HDAC1 | MAOA 707/4885MAOB 1079/4885ALDH1A1 97/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.