Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GLRA1 | P23415 | 1/20 | 0.56 |
| ▸ | RXRA | P19793 | 1/20 | 0.50 |
| ▸ | RXRB | P28702 | 1/20 | 0.50 |
| ▸ | RXRG | P48443 | 1/20 | 0.50 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 3/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.49 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.48 |
| ▸ | RAB9A | P51151 | 2/20 | 0.48 |
| ▸ | NPC1 | O15118 | 1/20 | 0.48 |
| ▸ | HPGD | P15428 | 1/20 | 0.48 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.47 |
| ▸ | MRGPRX4 | Q96LA9 | 5/20 | 0.47 |
| ▸ | SMPD1 | P17405 | 1/20 | 0.47 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.47 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.47 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.47 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12563268 | 0.88 | RXRA (0.60) | RXRARXRBRXRGFFAR4MAPT | |
| SCHEMBL2670990 | 0.87 | MRGPRX4 (0.55) | GLRA1RXRARXRBRXRGMAPT | |
| SCHEMBL16902987 | 0.87 | GLRA1 (0.61) | GLRA1RXRARXRBRXRGFFAR4 | |
| SCHEMBL2671557 | 0.86 | GLRA1 (0.53) | GLRA1RXRARXRBRXRGMAPT | |
| SCHEMBL71526 | 0.84 | RXRA (0.58) | GLRA1RXRARXRBRXRGFFAR4 | |
| SCHEMBL7783922 | 0.84 | FFAR4 (0.60) | GLRA1RXRARXRBRXRGFFAR4 | |
| SCHEMBL348412 | 0.84 | GLRA1 (0.68) | GLRA1RXRARXRBRXRGFFAR4 | |
| SCHEMBL514495 | 0.82 | GLRA1 (0.65) | GLRA1RXRARXRBSMN1; SMN2RAB9A | |
| SCHEMBL11345190 | 0.81 | GLRA1 (0.60) | GLRA1RXRASMN1; SMN2RAB9ANPC1 | |
| SCHEMBL5838451 | 0.80 | MEN1 (0.63) | RXRARXRBRXRGMAPTL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10000443-B2 | Compositions and methods for glucose transport inhibition | OHIO UNIVERSITY (US) | 2018-06-19 | — | — | US | disclosed |
| US-9399631-B2 | Polyphenol proteasome inhibitors, synthesis, and methods of use | UNIVERSITY OF SOUTH FLORIDA (US) | 2016-07-26 | — | — | US | disclosed |
| US-20160137585-A1 | COMPOSITIONS AND METHODS FOR GLUCOSE TRANSPORT INHIBITION | OHIO UNIVERSITY (US) | 2016-05-19 | — | — | US | disclosed |
| US-9181162-B2 | Compositions and methods for glucose transport inhibition | OHIO UNIVERSITY (US) | 2015-11-10 | — | — | US | disclosed |
| US-20140045931-A1 | POLYPHENOL PROTEASOME INHIBITORS, SYNTHESIS, AND METHODS OF USE | THE HONG KONG POLYTECHNIC UNIVERSITY (HK) | 2014-02-13 | — | — | US | disclosed |
| US-8563607-B2 | Polyphenol proteasome inhibitors, synthesis, and methods of use | UNIVERSITY OF SOUTH FLORIDA (US) | 2013-10-22 | — | — | US | disclosed |
| US-20120121536-A1 | COMPOSITIONS AND METHODS FOR GLUCOSE TRANSPORT INHIBITION | OHIO UNIVERSITY (US) | 2012-05-17 | — | — | US | disclosed |
| US-20120029067-A1 | Polyphenol Proteasome Inhibitors, Synthesis, and Methods of Use | UNIVERSITY OF SOUTH FLORIDA (US) | 2012-02-02 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140045931-A1 | POLYPHENOL PROTEASOME INHIBITORS, SYNTHESIS, AND METHODS OF USE | PSMC1, PSMB5, PSMC5 | GLRA1 4348/4885RXRA 3407/4885RXRB 3465/4885 |
| US-20160137585-A1 | COMPOSITIONS AND METHODS FOR GLUCOSE TRANSPORT INHIBITION | SLC2A1, SLC2A4, SLC2A3 | GLRA1 1309/4885RXRA 2450/4885RXRB 1689/4885 |
| US-20120121536-A1 | COMPOSITIONS AND METHODS FOR GLUCOSE TRANSPORT INHIBITION | SLC2A1, SLC2A4, SLC2A3 | GLRA1 1309/4885RXRA 2450/4885RXRB 1689/4885 |
| US-20120029067-A1 | Polyphenol Proteasome Inhibitors, Synthesis, and Methods of Use | PSMC1, PSMB5, PSMC5 | GLRA1 4348/4885RXRA 3407/4885RXRB 3465/4885 |
| US-10000443-B2 | Compositions and methods for glucose transport inhibition | SLC2A1, SLC2A4, SLC2A3 | GLRA1 1309/4885RXRA 2450/4885RXRB 1689/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.