Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 5/20 | 0.63 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.50 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.50 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.50 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.50 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.50 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.50 |
| ▸ | DRD1 | P21728 | 1/20 | 0.50 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.50 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.50 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.50 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.50 |
| ▸ | HRH1 | P35367 | 1/20 | 0.50 |
| ▸ | DRD3 | P35462 | 1/20 | 0.50 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.50 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.50 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.50 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.50 |
| ▸ | CYP2D6 | P10635 | 4/20 | 0.49 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16436972 | 0.86 | CYP1A2 (0.62) | SIGMAR1HRH3CYP2D6CYP1A2CYP2C19 | |
| SCHEMBL6743530 | 0.83 | SIGMAR1 (0.66) | SIGMAR1KCNH2ADRB2ADORA3CHRM1 | |
| SCHEMBL6272433 | 0.83 | LPL (0.62) | ADORA3CHRM1ADRA2BADRA2CSLC6A2 | |
| SCHEMBL19697582 | 0.83 | SIGMAR1 (0.65) | SIGMAR1KCNH2ADRB2ADORA3CHRM1 | |
| SCHEMBL9752244 | 0.83 | SIGMAR1 (0.65) | SIGMAR1KCNH2ADRB2ADORA3CHRM1 | |
| SCHEMBL7257290 | 0.81 | LPL (0.61) | ADORA3CHRM1ADRA2BADRA2CSLC6A2 | |
| SCHEMBL23073882 | 0.80 | SIGMAR1 (0.96) | SIGMAR1KCNH2ADRB2ADORA3CHRM1 | |
| SCHEMBL3996132 | 0.80 | SIGMAR1 (0.96) | SIGMAR1KCNH2ADRB2ADORA3CHRM1 | |
| SCHEMBL10802395 | 0.80 | SIGMAR1 (0.96) | SIGMAR1KCNH2ADRB2ADORA3CHRM1 | |
| SCHEMBL2322760 | 0.80 | SIGMAR1 (0.96) | SIGMAR1KCNH2ADRB2ADORA3CHRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050075377-A1 | PPAR compounds | PFIZER INC | 2005-04-07 | — | — | US | disclosed |
| EP-1372632-A1 | PROLIFERATIVE ACTIVATOR RECEPTOR (PPAR) COMPOUNDS | Pfizer Products Inc. (US) | 2004-01-02 | — | — | EP | disclosed |
| US-20020169192-A1 | PPAR compounds | HAYWARD CHERYL M (US) | 2002-11-14 | — | — | US | disclosed |
| WO-2002064130-A1 | PROLIFERATIVE ACTIVATOR RECEPTOR (PPAR) COMPOUNDS | PFIZER PRODUCTS INC. (US) | 2002-08-22 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020169192-A1 | PPAR compounds | PPARA, PPARG, PPARD | SIGMAR1 1433/4885KCNH2 4703/4885ADRB2 232/4885 |
| US-20050075377-A1 | PPAR compounds | PPARA, PPARG, PPARD | SIGMAR1 1433/4885KCNH2 4703/4885ADRB2 232/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.