Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LAP3 | P28838 | 5/20 | 0.54 |
| ▸ | ANPEP | P15144 | 1/20 | 0.54 |
| ▸ | RNPEP | Q9H4A4 | 1/20 | 0.54 |
| ▸ | DNPEP | Q9ULA0 | 1/20 | 0.54 |
| ▸ | LTA4H | P09960 | 2/20 | 0.50 |
| ▸ | SLC15A1 | P46059 | 1/20 | 0.50 |
| ▸ | MMP9 | P14780 | 1/20 | 0.49 |
| ▸ | MMP8 | P22894 | 1/20 | 0.49 |
| ▸ | MMP14 | P50281 | 1/20 | 0.49 |
| ▸ | ALPI | P09923 | 1/20 | 0.49 |
| ▸ | PKM | P14618 | 1/20 | 0.49 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.49 |
| ▸ | XIAP | P98170 | 1/20 | 0.49 |
| ▸ | SLC7A5 | Q01650 | 1/20 | 0.49 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
| ▸ | PYGL | P06737 | 1/20 | 0.46 |
| ▸ | METAP2 | P50579 | 1/20 | 0.46 |
| ▸ | CSNK1E | P49674 | 1/20 | 0.45 |
| ▸ | SLC1A3 | P43003 | 1/20 | 0.45 |
| ▸ | SLC1A2 | P43004 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3131492 | 1.00 | LAP3 (0.54) | LAP3ANPEPRNPEPDNPEPLTA4H | |
| SCHEMBL5885156 | 0.84 | LTA4H (0.52) | LAP3ANPEPRNPEPDNPEPLTA4H | |
| Hydrochloric Acid SCHEMBL6350217 | 0.83 | LTA4H (0.51) | LAP3ANPEPRNPEPDNPEPLTA4H | |
| SCHEMBL6873957 | 0.81 | LAP3 (0.46) | LAP3ANPEPRNPEPDNPEPLTA4H | |
| SCHEMBL26954884 | 0.81 | ALPI (0.63) | ANPEPRNPEPDNPEPLTA4HSLC15A1 | |
| SCHEMBL1764633 | 0.81 | ALPI (0.63) | ANPEPRNPEPDNPEPLTA4HSLC15A1 | |
| SCHEMBL30959049 | 0.81 | ALPI (0.63) | ANPEPRNPEPDNPEPLTA4HSLC15A1 | |
| SCHEMBL836806 | 0.81 | ALPI (0.63) | ANPEPRNPEPDNPEPLTA4HSLC15A1 | |
| SCHEMBL7959353 | 0.81 | ALPI (0.58) | LAP3ANPEPRNPEPDNPEPLTA4H | |
| SCHEMBL6321788 | 0.81 | ALPI (0.58) | LAP3ANPEPRNPEPDNPEPLTA4H |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6960575-B2 | For use as inhibitors of chymase | SANTEN PHARMACEUTICAL CO., LTD. (JP) | 2005-11-01 | — | — | US | disclosed |
| US-6713472-B1 | 2-OXO-1,2,3,4-TETRAHYDROPYRAZINE DERIVATIVES; CHYMASE INHIBITORS | SANTEN PHARMACEUTICAL CO., LTD. (JP) | 2004-03-30 | — | — | US | disclosed |