Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LTA4H | P09960 | 6/20 | 0.41 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.36 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.36 |
| ▸ | PPARA | Q07869 | 4/20 | 0.35 |
| ▸ | PPARG | P37231 | 2/20 | 0.35 |
| ▸ | CYP4Z1 | Q86W10 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | NAMPT | P43490 | 1/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.34 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.34 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.33 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.33 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.33 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.33 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.33 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6747532 | 0.89 | CYP4Z1 (0.41) | LTA4HHDAC8CYP4Z1ALDH1A1NAMPT | |
| SCHEMBL6746587 | 0.75 | EPHX2 (0.34) | LTA4HEPHX2HDAC8CYP4Z1ALDH1A1 | |
| SCHEMBL6361340 | 0.75 | LTA4H (0.37) | LTA4HHDAC8PPARAPPARGCYP2D6 | |
| SCHEMBL6360227 | 0.74 | PPARA (0.42) | EPHX2PPARAPPARGALDH1A1HDAC3 | |
| SCHEMBL6360224 | 0.74 | PPARA (0.42) | EPHX2PPARAPPARGALDH1A1HDAC3 | |
| SCHEMBL7863637 | 0.72 | HDAC8 (0.39) | LTA4HHDAC8CYP2D6KCNH2 | |
| SCHEMBL6744039 | 0.71 | LTA4H (0.41) | LTA4HEPHX2HDAC8CYP4Z1 | |
| SCHEMBL6746616 | 0.70 | LTA4H (0.44) | LTA4HHDAC8KCNH2HDAC3HDAC1 | |
| SCHEMBL6746546 | 0.70 | LTA4H (0.44) | LTA4HHDAC8PPARAPPARGHDAC3 | |
| SCHEMBL16747377 | 0.69 | PPARA (0.53) | LTA4HPPARAPPARGCYP4Z1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050075377-A1 | PPAR compounds | PFIZER INC | 2005-04-07 | — | — | US | disclosed |
| EP-1372632-A1 | PROLIFERATIVE ACTIVATOR RECEPTOR (PPAR) COMPOUNDS | Pfizer Products Inc. (US) | 2004-01-02 | — | — | EP | disclosed |
| US-20020169192-A1 | PPAR compounds | HAYWARD CHERYL M (US) | 2002-11-14 | — | — | US | disclosed |
| WO-2002064130-A1 | PROLIFERATIVE ACTIVATOR RECEPTOR (PPAR) COMPOUNDS | PFIZER PRODUCTS INC. (US) | 2002-08-22 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020169192-A1 | PPAR compounds | PPARA, PPARG, PPARD | LTA4H 848/4885EPHX2 3414/4885HDAC8 474/4885 |
| US-20050075377-A1 | PPAR compounds | PPARA, PPARG, PPARD | LTA4H 848/4885EPHX2 3414/4885HDAC8 474/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.