Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP19A1 | P11511 | 8/20 | 0.52 |
| ▸ | CYP11B2 | P19099 | 7/20 | 0.52 |
| ▸ | CYP11B1 | P15538 | 5/20 | 0.52 |
| ▸ | CES1 | P23141 | 1/20 | 0.48 |
| ▸ | MAOB | P27338 | 2/20 | 0.47 |
| ▸ | MIF | P14174 | 5/20 | 0.46 |
| ▸ | PKM | P14618 | 4/20 | 0.43 |
| ▸ | NPC1 | O15118 | 4/20 | 0.43 |
| ▸ | RAB9A | P51151 | 4/20 | 0.43 |
| ▸ | MAPT | P10636 | 3/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | ATM | Q13315 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.42 |
| ▸ | RELA | Q04206 | 1/20 | 0.42 |
| ▸ | SETD7 | Q8WTS6 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL636343 | 1.00 | CYP19A1 (0.52) | CYP19A1CYP11B2CYP11B1CES1MAOB | |
| SCHEMBL636341 | 1.00 | CYP19A1 (0.52) | CYP19A1CYP11B2CYP11B1CES1MAOB | |
| SCHEMBL22368864 | 0.87 | CYP19A1 (0.54) | CYP19A1CYP11B2CYP11B1MAOBMIF | |
| SCHEMBL6825997 | 0.87 | CYP19A1 (0.54) | CYP19A1CYP11B2CYP11B1MAOBMIF | |
| SCHEMBL20227832 | 0.87 | CYP19A1 (0.54) | CYP19A1CYP11B2CYP11B1MAOBMIF | |
| SCHEMBL21469218 | 0.84 | MAOB (0.64) | CYP19A1CYP11B2CES1MAOBMIF | |
| SCHEMBL14183852 | 0.84 | MAOB (0.64) | CYP19A1CYP11B2CES1MAOBMIF | |
| SCHEMBL8859036 | 0.79 | CES1 (0.56) | CYP19A1CYP11B2CYP11B1CES1MAOB | |
| Dihydrophenanthrene SCHEMBL155991 | 0.74 | CES1 (0.68) | CYP19A1CYP11B2CYP11B1CES1MAOB | |
| Dihydrophenanthrene SCHEMBL29404495 | 0.74 | CES1 (0.68) | CYP19A1CYP11B2CYP11B1CES1MAOB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 18 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10100198-B2 | Application of reduced dyes in imaging | LI-COR, INC. (US) | 2018-10-16 | — | — | US | disclosed |
| EP-2419478-B1 | FLUORESCENT IMAGING WITH SUBSTITUTED CYANINE DYES | LI COR INC (US) | 2018-02-28 | — | — | EP | disclosed |
| EP-2630196-B1 | CYANINE DYES AND THEIR CONJUGATES | LI COR INC (US) | 2017-09-06 | — | — | EP | disclosed |
| US-20170130050-A1 | APPLICATION OF REDUCED DYES IN IMAGING | LI-COR, INC. (US) | 2017-05-11 | — | — | US | disclosed |
| US-9470691-B2 | Application of reduced dyes in imaging | LI-COR, INC. (US) | 2016-10-18 | — | — | US | disclosed |
| US-9408924-B2 | Bioconjugates of cyanine dyes | LI-COR, INC. (US) | 2016-08-09 | — | — | US | disclosed |
| US-9248203-B2 | Fluorescent imaging with substituted cyanine dyes | LI-COR, INC. (US) | 2016-02-02 | — | — | US | disclosed |
| US-9089603-B2 | Fluorescent imaging with substituted cyanine dyes | LI-COR, INC. (US) | 2015-07-28 | — | — | US | disclosed |
| US-20150119553-A1 | BIOCONJUGATES OF CYANINE DYES | LI-COR, INC. | 2015-04-30 | — | — | US | disclosed |
| US-8927719-B2 | Cyanine dyes and their conjugates | LI-COR, INC. (US) | 2015-01-06 | — | — | US | disclosed |
| US-20140213473-A1 | APPLICATION OF REDUCED DYES IN IMAGING | LI-COR, INC. | 2014-07-31 | — | — | US | disclosed |
| US-20130280172-A1 | FLUORESCENT IMAGING WITH SUBSTITUTED CYANINE DYES | MIDCAP FINANCIAL TRUST | 2013-10-24 | — | — | US | disclosed |
| US-20130274452-A1 | CYANINE DYES AND THEIR CONJUGATES | MIDCAP FINANCIAL TRUST | 2013-10-17 | — | — | US | disclosed |
| US-8481752-B2 | Fluorescent imaging with substituted cyanine dyes | LI-COR, INC. (US) | 2013-07-09 | — | — | US | disclosed |
| US-20130039860-A1 | FLUORESCENT IMAGING WITH SUBSTITUTED CYANINE DYES | LI-COR, INC. (US) | 2013-02-14 | — | — | US | disclosed |
| EP-2419478-A2 | FLUORESCENT IMAGING WITH SUBSTITUTED CYANINE DYES | LI-COR, INC. (US) | 2012-02-22 | — | — | EP | disclosed |
| US-20100323389-A1 | FLUORESCENT IMAGING WITH SUBSTITUTED CYANINE DYES | LI-COR, INC. (US) | 2010-12-23 | — | — | US | disclosed |
| WO-2010121163-A2 | FLUORESCENT IMAGING WITH SUBSTITUTED CYANINE DYES | LI-COR, INC. (US) | 2010-10-21 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130274452-A1 | CYANINE DYES AND THEIR CONJUGATES | FCGR3B, QPCT, TIE1 | CYP19A1 1693/4885CYP11B2 2388/4885CYP11B1 1959/4885 |
| US-10100198-B2 | Application of reduced dyes in imaging | HMOX2, HCCS, HMOX1 | CYP19A1 3058/4885CYP11B2 910/4885CYP11B1 763/4885 |
| US-20130280172-A1 | FLUORESCENT IMAGING WITH SUBSTITUTED CYANINE DYES | TIE1, ALG1, MSR1 | CYP19A1 2761/4885CYP11B2 3222/4885CYP11B1 2853/4885 |
| US-20100323389-A1 | FLUORESCENT IMAGING WITH SUBSTITUTED CYANINE DYES | MSR1, TIE1, ALG1 | CYP19A1 3052/4885CYP11B2 3248/4885CYP11B1 2877/4885 |
| US-20150119553-A1 | BIOCONJUGATES OF CYANINE DYES | FCGR3B, FCGR2A, HCCS | CYP19A1 1995/4885CYP11B2 1348/4885CYP11B1 2111/4885 |
| US-20130039860-A1 | FLUORESCENT IMAGING WITH SUBSTITUTED CYANINE DYES | TIE1, ALG1, MSR1 | CYP19A1 2761/4885CYP11B2 3222/4885CYP11B1 2853/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.