Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC22A12 | Q96S37 | 3/20 | 0.39 |
| ▸ | DYRK1A | Q13627 | 12/20 | 0.38 |
| ▸ | ESR1 | P03372 | 1/20 | 0.37 |
| ▸ | KMO | O15229 | 1/20 | 0.37 |
| ▸ | HTR2A | P28223 | 1/20 | 0.37 |
| ▸ | HTR2C | P28335 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7994539 | 0.79 | ALDH1A1 (0.38) | SLC22A12DYRK1AESR1ALDH1A1KMT2A | |
| SCHEMBL7011042 | 0.75 | DYRK1A (0.41) | SLC22A12DYRK1AKMOHTR2AHTR2C | |
| SCHEMBL7777139 | 0.75 | SLC22A12 (0.39) | SLC22A12DYRK1AKMOHTR2AHTR2C | |
| SCHEMBL14487582 | 0.74 | SLC22A12 (0.52) | SLC22A12DYRK1AKMOKMT2A | |
| SCHEMBL6361835 | 0.74 | SLC22A12 (0.46) | SLC22A12DYRK1AKMOALDH1A1KMT2A | |
| Fumaric Acid SCHEMBL6364117 | 0.72 | HTR2C (0.48) | SLC22A12DYRK1AKMOHTR2AHTR2C | |
| Fumaric Acid SCHEMBL6364123 | 0.72 | HTR2C (0.48) | SLC22A12DYRK1AKMOHTR2AHTR2C | |
| Fumaric Acid SCHEMBL5678095 | 0.72 | HTR2C (0.48) | SLC22A12DYRK1AKMOHTR2AHTR2C | |
| Fumaric Acid SCHEMBL5678109 | 0.72 | HTR2C (0.48) | SLC22A12DYRK1AKMOHTR2AHTR2C | |
| Fumaric Acid SCHEMBL5678103 | 0.72 | DYRK1A (0.49) | SLC22A12DYRK1AKMOHTR2AHTR2C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6956036-B1 | 6-hydroxy-indazole derivatives for treating glaucoma | ALCON, INC. (CH) | 2005-10-18 | — | — | US | disclosed |
| EP-1268438-A1 | 6-HYDROXY-INDAZOLE DERIVATIVES FOR TREATING GLAUCOMA | Alcon, Inc (CH) | 2003-01-02 | — | — | EP | disclosed |
| WO-2001070702-A1 | 6-HYDROXY-INDAZOLE DERIVATIVES FOR TREATING GLAUCOMA | ALCON, INC. (CH) | 2001-09-27 | — | — | WO | disclosed |