Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | PDE4A | P27815 | 2/20 | 0.38 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.38 |
| ▸ | PDE4C | Q08493 | 2/20 | 0.38 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.37 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.37 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.37 |
| ▸ | ESR1 | P03372 | 1/20 | 0.37 |
| ▸ | CNR1 | P21554 | 3/20 | 0.36 |
| ▸ | CNR2 | P34972 | 2/20 | 0.36 |
| ▸ | PLA2G2A | P14555 | 3/20 | 0.35 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.35 |
| ▸ | SLC22A12 | Q96S37 | 1/20 | 0.34 |
| ▸ | PLA2G10 | O15496 | 1/20 | 0.34 |
| ▸ | HTR6 | P50406 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6364121 | 0.79 | SLC22A12 (0.39) | ALDH1A1KMT2AESR1DYRK1ASLC22A12 | |
| SCHEMBL8959747 | 0.79 | AR (0.44) | ALDH1A1 | |
| SCHEMBL8959949 | 0.77 | SLC22A12 (0.35) | PDE4APDE4BPDE4CPDE4DKMT2A | |
| SCHEMBL8959667 | 0.73 | TRPM5 (0.38) | PLA2G2A | |
| SCHEMBL8959711 | 0.72 | HTR2C (0.45) | ALDH1A1MEN1KMT2A | |
| Fumaric Acid SCHEMBL7994542 | 0.72 | HTR2C (0.46) | PDE4APDE4BPDE4CPDE4DMEN1 | |
| Maleic Acid SCHEMBL7994532 | 0.72 | HTR2C (0.46) | PDE4APDE4BPDE4CPDE4DMEN1 | |
| SCHEMBL7850213 | 0.71 | HTR6 (0.49) | ALDH1A1PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL8959547 | 0.70 | HTR2C (0.45) | HDAC1HDAC2HDAC6 | |
| SCHEMBL27342171 | 0.70 | HTR2C (0.45) | HDAC1HDAC2HDAC6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2001040183-A1 | 1-AMINOALKYL-1H-INDOLES FOR TREATING GLAUCOMA | ALCON UNIVERSAL LTD. (CH) | 2001-06-07 | — | — | WO | disclosed |