SCHEMBL636416

SCHEMBL636416

O=C1C=C(Nc2ccc(O)cc2)C(=O)C=C1Nc1ccc(O)cc1

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ DNM1 Q05193 1/20 1.00
▸ MAPT P10636 9/20 0.62
▸ RAB9A P51151 5/20 0.62
▸ MAPK1 P28482 5/20 0.62
▸ BLM P54132 3/20 0.62
▸ TDP1 Q9NUW8 2/20 0.62
▸ JAK2 O60674 1/20 0.62
▸ EPHB2 P29323 1/20 0.62
▸ CDK4 P11802 1/20 0.50
▸ PRKD3 O94806 1/20 0.44
▸ ABL1 P00519 1/20 0.44
▸ EGFR P00533 1/20 0.44
▸ PRKCG P05129 1/20 0.44
▸ PRKCB P05771 1/20 0.44
▸ SRC P12931 1/20 0.44
▸ PRKCA P17252 1/20 0.44
▸ PRKCH P24723 1/20 0.44
▸ PRKCI P41743 1/20 0.44
▸ ABL2 P42684 1/20 0.44
▸ PRKCE Q02156 1/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL15019989 0.86 DNM1 (0.73) DNM1MAPTRAB9AMAPK1BLM
SCHEMBL15022768 0.84 DNM1 (0.71) DNM1MAPTRAB9AMAPK1BLM
SCHEMBL11419341 0.84 DNM1 (0.71) DNM1MAPTRAB9AMAPK1BLM
SCHEMBL11805322 0.84 DNM1 (0.71) DNM1MAPTRAB9AMAPK1BLM
SCHEMBL15020045 0.83 DNM1 (0.69) DNM1MAPTRAB9AMAPK1BLM
SCHEMBL15039495 0.83 DNM1 (0.69) DNM1MAPTRAB9AMAPK1BLM
SCHEMBL15020041 0.83 DNM1 (0.69) DNM1MAPTRAB9AMAPK1BLM
SCHEMBL15020366 0.78 DNM1 (0.61) DNM1MAPTRAB9AMAPK1BLM
SCHEMBL15039538 0.78 DNM1 (0.61) DNM1MAPTRAB9AMAPK1BLM
SCHEMBL15039490 0.78 DNM1 (0.61) DNM1MAPTRAB9AMAPK1BLM

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20230142547-A1 COMPOUNDS FOR TREATING OR PREVENTING A CORONAVIRIDAE INFECTION & METHODS AND USES FOR ASSESSING THE OCCURRENCE OF A CORONAVIRIDAE INFECTION ABIVAX (FR) 2023-05-11 — — US disclosed
EP-4121053-A1 COMPOUNDS FOR TREATING OR PREVENTING A CORONAVIRIDAE INFECTION & METHODS AND USES FOR ASSESSING THE OCCURRENCE OF A CORONAVIRIDAE INFECTION ABIVAX (FR) 2023-01-25 — — EP disclosed
CN-115605205-A Compounds for treating or preventing infections of the family coronaviridae and methods and uses for assessing the occurrence of infections of the family coronaviridae ABIVAX公司(FR) 2023-01-13 — — CN disclosed
WO-2021186053-A1 COMPOUNDS FOR TREATING OR PREVENTING A CORONAVIRIDAE INFECTION & METHODS AND USES FOR ASSESSING THE OCCURRENCE OF A CORONAVIRIDAE INFECTION ABIVAX (FR) 2021-09-23 — — WO disclosed
US-8668821-B2 Detection of phenols ISIS INNOVATION LIMITED (GB) 2014-03-11 — — US disclosed
US-20130098779-A1 Detection of Phenols ISIS INNOVATION LIMITED (GB) 2013-04-25 — — US disclosed
EP-1891423-B1 DETECTION OF PHENOLS ISIS INNOVATION (GB) 2012-02-22 — — EP disclosed
US-20090294298-A1 Detection of Phenols ISIS INNOVATION LIMITED (GB) 2009-12-03 — — US disclosed
EP-1891423-A1 DETECTION OF PHENOLS Isis Innovation Limited (GB) 2008-02-27 — — EP disclosed
WO-2006134386-A1 DETECTION OF PHENOLS ISIS INNOVATION LIMITED (GB) 2006-12-21 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20230142547-A1 COMPOUNDS FOR TREATING OR PREVENTING A CORONAVIRIDAE INFECTION & METHODS AND USES FOR ASSESSING THE OCCURRENCE OF A CORONAVIRIDAE INFECTION ACE, ACE2, SARS1 DNM1 1018/4885MAPT 1440/4885RAB9A 4206/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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