Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.39 |
| ▸ | HPGD | P15428 | 3/20 | 0.39 |
| ▸ | PARP1 | P09874 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | PKM | P14618 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | PTK2B | Q14289 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 2/20 | 0.35 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | HRH1 | P35367 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6364991 | 1.00 | LMNA (0.40) | LMNAKDM4EALDH1A1HPGDPARP1 | |
| SCHEMBL14387230 | 0.84 | LMNA (0.41) | LMNAKDM4EALDH1A1HPGDPARP1 | |
| SCHEMBL6370665 | 0.79 | PARP1 (0.38) | LMNAKDM4EALDH1A1HPGDPARP1 | |
| SCHEMBL6370673 | 0.79 | PARP1 (0.38) | LMNAKDM4EALDH1A1HPGDPARP1 | |
| SCHEMBL6368595 | 0.79 | KDM4E (0.39) | LMNAKDM4EALDH1A1HPGDCYP1A2 | |
| SCHEMBL6369104 | 0.75 | MAPK1 (0.45) | LMNAKDM4EALDH1A1HPGDPOLB | |
| SCHEMBL18912080 | 0.75 | ALDH1A1 (0.39) | LMNAKDM4EALDH1A1HPGDPARP1 | |
| SCHEMBL6364102 | 0.74 | LMNA (0.45) | LMNAKDM4EALDH1A1SMN1; SMN2RAB9A | |
| SCHEMBL6364105 | 0.74 | LMNA (0.45) | LMNAKDM4EALDH1A1SMN1; SMN2RAB9A | |
| SCHEMBL21803732 | 0.73 | GRIN2D (0.47) | LMNAKDM4EALDH1A1HPGDMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050070591-A1 | Indole derivative | KYOWA HAKKO KOGYO CO., LTD. (JP) | 2005-03-31 | — | — | US | disclosed |
| EP-1464645-A1 | INDOLE DERIVATIVE | KYOWA HAKKO KOGYO CO., LTD. (JP) | 2004-10-06 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050070591-A1 | Indole derivative | TPH1, IDO1, RBX1 | LMNA 4014/4885KDM4E 1406/4885ALDH1A1 1318/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.