SCHEMBL6366

SCHEMBL6366

O=C(O)C(O)c1ccc(Cl)cc1

nearest known ligand 0.62

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
LMNA P02545 4/20 0.62
MAPK1 P28482 1/20 0.62
CYP2C9 P11712 4/20 0.47
CYP2C19 P33261 3/20 0.47
MEN1 O00255 2/20 0.47
CYP2D6 P10635 2/20 0.47
KMT2A Q03164 2/20 0.47
BRD4 O60885 1/20 0.47
HDAC4 P56524 1/20 0.47
HDAC7 Q8WUI4 1/20 0.47
HDAC5 Q9UQL6 1/20 0.47
HSD17B10 Q99714 1/20 0.47
TSHR P16473 4/20 0.46
ALOX15 P16050 2/20 0.46
GABBR2 O75899 3/20 0.46
GABBR1 Q9UBS5 3/20 0.46
BLM P54132 2/20 0.46
CYP3A4 P08684 1/20 0.46
ADORA3 P0DMS8 1/20 0.46
NFKB1 P19838 1/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2163167 1.00 LMNA (0.62) LMNAMAPK1CYP2C9CYP2C19MEN1
SCHEMBL29903923 1.00 LMNA (0.62) LMNAMAPK1CYP2C9CYP2C19MEN1
SCHEMBL6367 1.00 LMNA (0.62) LMNAMAPK1CYP2C9CYP2C19MEN1
SCHEMBL11652701 0.98 LMNA (0.60) LMNAMAPK1CYP2C9CYP2C19MEN1
SCHEMBL8997384 0.94 LMNA (0.56) LMNAMAPK1CYP2C9CYP2C19MEN1
Chlorobenzene SCHEMBL8754828 0.94 LMNA (0.68) LMNAMAPK1CYP2C9CYP2C19MEN1
SCHEMBL7566668 0.92 LMNA (0.54) LMNAMAPK1CYP2C9CYP2C19MEN1
Deaminohydroxyvaline SCHEMBL9069626 0.88 LMNA (0.50) LMNAMAPK1CYP2C9CYP2C19MEN1
Alanine SCHEMBL11206225 0.88 LMNA (0.50) LMNAMAPK1CYP2C9CYP2C19MEN1
D-Alanine SCHEMBL11211250 0.88 LMNA (0.50) LMNAMAPK1CYP2C9CYP2C19MEN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1049 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-117945937-B Method for preparing high-optical-purity sulbactam besylate 重庆华森制药股份有限公司 2024-07-30 CN claimed
CN-117945937-A Method for preparing high-optical-purity sulbactam besylate 重庆华森制药股份有限公司 2024-04-30 CN claimed
CN-113355367-B Application of ketoacid reductase in synthesis of chiral aromatic 2-hydroxy acid 浙江工业大学 2024-03-26 CN claimed
CN-113801239-B Polypeptide tag, highly soluble recombinant nitrilase and application thereof in synthesis of medicinal chemicals 浙江工业大学 2023-10-20 CN claimed
CN-108884081-B Process for separating enantiomers of piperazine derivatives 阿森纽荣股份公司 2022-11-01 CN claimed
CN-111056890-B Method for preparing aryl ketone by free radical-free radical coupling reaction of ketoacid decarboxylation and fatty aldehyde decarbonylation based on iron catalysis 湘潭大学 2022-10-14 CN claimed
US-20220325035-A1 POLYESTER, POLYESTERAMIDE, AND POLYAMIDE COMPOSITIONS IYER ANANTH V (US) 2022-10-13 US claimed
CN-113355299-B Ketoacid reductase, gene, engineering bacterium and application in synthesis of chiral aromatic 2-hydroxy acid 浙江工业大学 2022-05-24 CN claimed
CN-114350326-A Coolant, preparation method thereof, temperature-sensitive flocculent gel and aerosol fire extinguishing device 湖北及安盾消防科技有限公司 2022-04-15 CN claimed
CN-110373762-B Preparation method of antibacterial blended yarn for underwear 海盐县硕创服装研究所 2022-04-12 CN claimed
EP-0413528-B1 Amphoteric compositions and polymeric forms of alpha hydroxyacids, and their therapeutic use YU RUEY J (US) 1995-11-15 EP claimed
EP-0273202-B1 Use of hydroxycarboxylic acids to enhance therapeutic effects of topical compositions for fungal infections and pigmented spots. SCOTT EUGENE J VAN (US) 1995-06-21 EP claimed
EP-0599819-A2 Additives enhancing topical actions of therapeutic agents Van Scott, Eugene J., Dr. (US) 1994-06-01 EP claimed
WO-1992018116-A1 COMPOSITIONS COMPRISING 2-HYDROXYCARBOXYLIC ACIDS AND RELATED COMPOUNDS, AND METHODS FOR ALLEVIATING SIGNS OF DERMATOLOGICAL AGING YU RUEY J (US) 1992-10-29 WO claimed
EP-0508324-A2 Compositions comprising 2-hydroxycarboxylic acids and related compounds, and methods for alleviating signs of dermatological aging Yu, Ruey J., Dr. (US) 1992-10-14 EP claimed
US-5091171-A Skin disorders IGI, INC. 1992-02-25 US claimed
EP-0413528-A1 Amphoteric compositions and polymeric forms of alpha hydroxyacids, and their therapeutic use Yu, Ruey J., Dr. (US) 1991-02-20 EP claimed
EP-0273202-A2 Use of hydroxycarboxylic acids to enhance therapeutic effects of topical compositions for fungal infections and pigmented spots. Van Scott, Eugene J., Dr. (US) 1988-07-06 EP claimed
US-4202699-A Lithoplates of quaternary ammonium salt compositions VICKERS LIMITED (GB) 1980-05-13 US claimed
US-4126468-A Radiation sensitive compositions of quaternary ammonium salt and carboxylic acid sensitizer VICKERS LIMITED (GB) 1978-11-21 US claimed