Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDK1 | Q15118 | 7/20 | 0.48 |
| ▸ | PDK2 | Q15119 | 7/20 | 0.48 |
| ▸ | PDK3 | Q15120 | 7/20 | 0.48 |
| ▸ | PDK4 | Q16654 | 7/20 | 0.48 |
| ▸ | JAK2 | O60674 | 1/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | KLK7 | P49862 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | PARP14 | Q460N5 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 3/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.39 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.39 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.39 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.39 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.39 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6367216 | 0.79 | SMN1; SMN2 (0.56) | PDK1PDK2PDK3PDK4JAK2 | |
| SCHEMBL3596918 | 0.78 | TP53 (0.50) | PDK1PDK2PDK3PDK4JAK2 | |
| SCHEMBL1576313 | 0.78 | PDK1 (0.67) | PDK1PDK2PDK3PDK4JAK2 | |
| SCHEMBL22262468 | 0.76 | MAPT (0.48) | PDK1PDK2PDK3PDK4JAK2 | |
| SCHEMBL20051277 | 0.76 | HDAC1 (0.51) | PDK1PDK2PDK3PDK4JAK2 | |
| SCHEMBL14764250 | 0.76 | HTT (0.48) | PDK1PDK2PDK3PDK4JAK2 | |
| SCHEMBL29659883 | 0.76 | MAPT (0.48) | PDK1PDK2PDK3PDK4JAK2 | |
| SCHEMBL10625596 | 0.72 | KMT2A (0.52) | PDK1PDK2PDK3PDK4JAK2 | |
| SCHEMBL4343335 | 0.72 | TAS1R3 (0.53) | PDK1PDK2PDK3PDK4JAK2 | |
| SCHEMBL3628825 | 0.72 | MAP2K2 (0.44) | PDK1PDK2PDK3PDK4MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6884801-B1 | Imidazoline derivatives as alpha-1A adrenoceptor ligands | SMITHKLINE BEECHAM CORPORATION (US) | 2005-04-26 | — | — | US | disclosed |
| EP-1175406-A1 | IMIDAZOLINE DERIVATIVES AS ALPHA-1A ADRENOCEPTOR LIGANDS | GLAXO GROUP LIMITED (GB) | 2002-01-30 | — | — | EP | disclosed |
| WO-2000066563-A1 | IMIDAZOLINE DERIVATIVES AS ALPHA-1A ADRENOCEPTOR LIGANDS | GLAXO GROUP LIMITED (GB) | 2000-11-09 | — | — | WO | disclosed |