Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.56 |
| ▸ | PDK1 | Q15118 | 3/20 | 0.51 |
| ▸ | PDK2 | Q15119 | 3/20 | 0.51 |
| ▸ | PDK3 | Q15120 | 3/20 | 0.51 |
| ▸ | PDK4 | Q16654 | 3/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.50 |
| ▸ | GAA | P10253 | 1/20 | 0.50 |
| ▸ | MAPT | P10636 | 2/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.48 |
| ▸ | JAK2 | O60674 | 1/20 | 0.48 |
| ▸ | TP53 | P04637 | 1/20 | 0.48 |
| ▸ | HTT | P42858 | 1/20 | 0.48 |
| ▸ | KLK7 | P49862 | 1/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 2/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | PARP14 | Q460N5 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14631798 | 0.86 | SMN1; SMN2 (0.56) | SMN1; SMN2PDK1PDK2PDK3PDK4 | |
| SCHEMBL6029980 | 0.84 | PDK1 (0.53) | PDK1PDK2PDK3PDK4ALDH1A1 | |
| SCHEMBL8403273 | 0.83 | HTT (0.48) | PDK1PDK2PDK3PDK4GAA | |
| SCHEMBL3596918 | 0.82 | TP53 (0.50) | SMN1; SMN2PDK1PDK2PDK3PDK4 | |
| SCHEMBL1576313 | 0.82 | PDK1 (0.67) | SMN1; SMN2PDK1PDK2PDK3PDK4 | |
| SCHEMBL2091236 | 0.82 | SMN1; SMN2 (0.68) | SMN1; SMN2ALDH1A1GAAMAPTLMNA | |
| SCHEMBL994038 | 0.81 | PDK1 (0.53) | SMN1; SMN2PDK1PDK2PDK3PDK4 | |
| SCHEMBL2091233 | 0.80 | SMN1; SMN2 (0.61) | SMN1; SMN2ALDH1A1GAAMAPTTP53 | |
| SCHEMBL863826 | 0.80 | SMN1; SMN2 (0.61) | SMN1; SMN2ALDH1A1GAALMNAPOLB | |
| SCHEMBL30002532 | 0.80 | SMN1; SMN2 (0.61) | SMN1; SMN2ALDH1A1GAALMNAPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6884801-B1 | Imidazoline derivatives as alpha-1A adrenoceptor ligands | SMITHKLINE BEECHAM CORPORATION (US) | 2005-04-26 | — | — | US | disclosed |
| EP-1175406-A1 | IMIDAZOLINE DERIVATIVES AS ALPHA-1A ADRENOCEPTOR LIGANDS | GLAXO GROUP LIMITED (GB) | 2002-01-30 | — | — | EP | disclosed |
| WO-2000066563-A1 | IMIDAZOLINE DERIVATIVES AS ALPHA-1A ADRENOCEPTOR LIGANDS | GLAXO GROUP LIMITED (GB) | 2000-11-09 | — | — | WO | disclosed |