Predicted protein targets (top 2)
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6369862 | 0.81 | KDR (0.48) | IRAK4 | |
| SCHEMBL6368598 | 0.77 | IRAK4 (0.48) | IRAK4 | |
| SCHEMBL6363667 | 0.75 | CD38 (0.41) | IRAK4CD38 | |
| SCHEMBL6363672 | 0.75 | CD38 (0.41) | IRAK4CD38 | |
| SCHEMBL6369876 | 0.75 | HPGDS (0.45) | IRAK4CD38 | |
| SCHEMBL6368444 | 0.74 | IRAK4 (0.45) | IRAK4CD38 | |
| SCHEMBL6363869 | 0.72 | CD38 (0.47) | CD38 | |
| SCHEMBL6364295 | 0.72 | AURKA (0.44) | IRAK4CD38 | |
| SCHEMBL6363927 | 0.71 | AURKA (0.49) | — | |
| SCHEMBL6363833 | 0.70 | CD38 (0.54) | IRAK4CD38 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005016925-A1 | AZAQUINAZOLINE DERIVATIVES | PFIZER LIMITED (GB) | 2005-02-24 | — | — | WO | disclosed |
| US-20050038047-A1 | Azaquinazoline derivatives | EDWARDS PAUL JOHN (GB) | 2005-02-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050038047-A1 | Azaquinazoline derivatives | AZI2, P2RX5, P2RX7 | IRAK4 1896/4885CD38 1418/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.